Document Detail

Combination therapy using 9,3"-di-O-acetyl-midecamycin with beta-lactam antibiotics against Pseudomonas aeruginosa infection.
MedLine Citation:
PMID:  6798249     Owner:  NLM     Status:  MEDLINE    
The combined effect of beta-lactam antibiotics and 9,3"-di-O-acetylmidecamycin were examined in 10 patients diagnosed as having chronic respiratory tract infections and complicated urinary tract infections. Patients were initially treated with 3 to 10 g/day of beta-lactams as intravenous infusions or by oral route for a certain period, after which period they were treated concurrently with 0.3 to 0.9 g/day of 9,3"-di-O-acetylmidecamycin by oral route. Through this combination therapy eradication of P. aeruginosa was obtained in 2 cases and remarkable decrease in another 2 cases out of the 10 cases. This combination therapy was judged to be effective in these 4 cases. Of the remaining cases, P. aeruginosa was eliminated before the start of the combination therapy in 3 cases, and no change in bacterial count was noted after the combination therapy in the other 3 cases.
K Mashimo; J Y Homma; Y Iki; K Inatomi; T Kasai; O Kunii; K Shimada; H Tanimoto; T Takigami; Y Nishimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Japanese journal of experimental medicine     Volume:  51     ISSN:  0021-5031     ISO Abbreviation:  Jpn. J. Exp. Med.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9800765     Medline TA:  Jpn J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  271-85     Citation Subset:  IM    
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MeSH Terms
Agammaglobulinemia / complications
Anti-Bacterial Agents / therapeutic use*
Bronchiectasis / drug therapy
Bronchitis / drug therapy
Drug Therapy, Combination
Leucomycins / therapeutic use*
Middle Aged
Pseudomonas Infections / drug therapy*,  microbiology
Pseudomonas aeruginosa / immunology
Pulmonary Emphysema / drug therapy
Urinary Bladder, Neurogenic / drug therapy
beta-Lactams / therapeutic use
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Leucomycins; 0/beta-Lactams; 55881-07-7/Miocamycin

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