| Combination therapy for life-threatening pulmonary hypertension in a premature infant: first report on bosentan use. | |
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MedLine Citation:
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PMID: 21380943 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Premature infants with preterm premature rupture of membranes (PPROM) are at high risk of severe respiratory failure because of lung hypodysplasia associated with persistent pulmonary hypertension of the newborn (PPHN). We describe the clinical course of a 28-week gestation infant with PPROM from the 20th week and prolonged oligohydramnios before delivery, who developed refractory hypoxia treated with oral bosentan as adjunct therapy to inhaled nitric oxide (iNO) and oral sildenafil. Conclusion Our experience suggests that bosentan can be used in the premature infant with PPHN after PPROM. To the best of our knowledge, this is the first report of bosentan treatment in a premature infant. |
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Authors:
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Maurizio Radicioni; Alessia Bruni; Piergiorgio Camerini |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-8 |
Journal Detail:
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Title: European journal of pediatrics Volume: - ISSN: 1432-1076 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Neonatal Intensive Care Unit, S. Maria della Misericordia Hospital of Perugia, S. Andrea delle Fratte, 06156, Perugia, Italy, maurizio.radicioni@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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