Document Detail

Combination therapy for life-threatening pulmonary hypertension in a premature infant: first report on bosentan use.
MedLine Citation:
PMID:  21380943     Owner:  NLM     Status:  MEDLINE    
Premature infants with preterm premature rupture of membranes (PPROM) are at high risk of severe respiratory failure because of lung hypodysplasia associated with persistent pulmonary hypertension of the newborn (PPHN). We describe the clinical course of a 28-week gestation infant with PPROM from the 20th week and prolonged oligohydramnios before delivery, who developed refractory hypoxia treated with oral bosentan as adjunct therapy to inhaled nitric oxide (iNO) and oral sildenafil. Conclusion Our experience suggests that bosentan can be used in the premature infant with PPHN after PPROM. To the best of our knowledge, this is the first report of bosentan treatment in a premature infant.
Maurizio Radicioni; Alessia Bruni; Piergiorgio Camerini
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-03-08
Journal Detail:
Title:  European journal of pediatrics     Volume:  170     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-19     Completed Date:  2012-03-16     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1075-8     Citation Subset:  IM    
Neonatal Intensive Care Unit, S. Maria della Misericordia Hospital of Perugia, S. Andrea delle Fratte, 06156, Perugia, Italy.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Drug Therapy, Combination
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / diagnosis,  drug therapy*
Nitric Oxide / therapeutic use*
Persistent Fetal Circulation Syndrome / diagnosis,  drug therapy*
Piperazines / therapeutic use*
Purines / therapeutic use
Sulfonamides / therapeutic use*
Sulfones / therapeutic use*
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Piperazines; 0/Purines; 0/Sulfonamides; 0/Sulfones; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 3M7OB98Y7H/sildenafil; Q326023R30/bosentan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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