| Combination therapy in rheumatoid arthritis--no benefit of addition of hydroxychloroquine to patients with a suboptimal response to intramuscular gold therapy. | |
| | |
MedLine Citation:
|
PMID: 8496858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To determine if there is any advantage in adding hydroxychloroquine to intramuscular gold therapy in patients with rheumatoid arthritis (RA) with a suboptimal response to gold after 6 months of treatment. METHODS: Prospective double blind placebo controlled study at the Centre for Rheumatic Diseases, Glasgow Royal Infirmary and Gartnavel General Hospital, Glasgow. Patients--440 patients with RA began intramuscular gold therapy. One hundred forty-two patients with a suboptimal response at 6 months were randomized to receive additional treatment with hydroxychloroquine (400 mg/day) or placebo, and followed for a further 6 months. Outcome measures were erythrocyte sedimentation rate, C-reactive protein, Ritchie articular index, grip strength, visual analog pain score, duration of morning stiffness, health assessment questionnaire, and rate of side effects. RESULTS: There was no difference in outcome in terms of efficacy or toxicity. CONCLUSION: There is no justification for using a combination of intramuscular gold and hydroxychloroquine in patients with RA with a partial response to gold. |
| | |
Authors:
|
D R Porter; H A Capell; J Hunter |
Related Documents
:
|
22837798 - Multistrain probiotic preparation significantly reduces symptoms of irritable bowel syn... 2871188 - Sulphasalazine in the treatment of juvenile rheumatoid arthritis: a preliminary open tr... 6391928 - Double-blind crossover study to evaluate the efficacy of a single daily dose of naproxe... 15660468 - Assessing the safety of biologic therapies in rheumatoid arthritis: the challenges of s... 19017828 - Tumor progression associated with erythropoiesis-stimulating agents. 12715628 - Clinical management of dialysis-related carnitine deficiency: three case studies. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: The Journal of rheumatology Volume: 20 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1993 Apr |
Date Detail:
|
Created Date: 1993-06-18 Completed Date: 1993-06-18 Revised Date: 2010-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
|
Languages: eng Pagination: 645-9 Citation Subset: IM |
Affiliation:
|
Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Scotland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Arthritis, Rheumatoid
/
blood,
drug therapy* Blood Sedimentation C-Reactive Protein / analysis Double-Blind Method Drug Therapy, Combination Gold / therapeutic use* Humans Hydroxychloroquine / therapeutic use* Injections, Intramuscular Middle Aged |
| Chemical | |
Reg. No./Substance:
|
118-42-3/Hydroxychloroquine; 7440-57-5/Gold; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Methotrexate therapy in rheumatoid arthritis: a life table review of 587 patients treated in communi...
Next Document: Fetal outcome of lupus pregnancy: a retrospective case-control study of the Hopkins Lupus Cohort.