| Combination therapies in spondyloarthropathies. | |
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MedLine Citation:
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PMID: 15659875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To compare the efficacy and tolerability of single-agent sulfasalazine (SSZ) with combination therapies composed of SSZ and methotrexate (MTX) and SSZ, MTX and hydroxychloroquine (HCQ) in active spondyloarthropathy (SpA) patients with peripheral arthritis. METHODS: One hundred and fifty SpA patients with peripheral arthritis (male/ female: 92/58) who were treated in our clinic between 1994 and 1998 were enrolled in this trial. Patients treated with SSZ alone (1-3 gr/day) were included in Group I, patients treated with combination of SSZ (1-3 gr/day) and MTX (7.5-15 mg/week) in Group II, and patients treated with combination of SSZ (1-3 gr/day), MTX (7.5-15 mg/week) and HCQ (200 mg/day) in Group III. Forty-eight patients in Group I, 45 patients in Group II and III were eligible for statistical analysis at the end of study. RESULTS: The combination of MTX, SSZ, and HCQ, and the combination of MTX and SSZ were more effective regarding the clinical and laboratory parameters than SSZ alone (p<0.05). Moreover, the combination of MTX, SSZ, and HCQ was more effective than the combination of MTX and SSZ (p<0.05). CONCLUSION: Combination therapies seem to be more effective and no more toxic than monotherapy in SpA patients with peripheral arthritis. |
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Authors:
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Meral Calgüneri; Veli Cobankara; M Akif Oztürk; Ihsan Ertenli; Sedat Kiraz; Sule Apraş |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: The Kobe journal of medical sciences Volume: 50 ISSN: 0023-2513 ISO Abbreviation: Kobe J Med Sci Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2005-01-20 Completed Date: 2005-03-21 Revised Date: 2008-04-08 |
Medline Journal Info:
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Nlm Unique ID: 0413531 Medline TA: Kobe J Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 31-7 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arthritis / drug therapy, radiography Drug Therapy, Combination* Female Humans Hydroxychloroquine / administration & dosage Male Methotrexate / administration & dosage Spondylarthropathies / drug therapy*, radiography Sulfasalazine / administration & dosage Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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118-42-3/Hydroxychloroquine; 59-05-2/Methotrexate; 599-79-1/Sulfasalazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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