Document Detail

Combination of surgery and chemotherapy and the role of targeted agents in the treatment of patients with colorectal liver metastases: recommendations from an expert panel.
MedLine Citation:
PMID:  19153115     Owner:  NLM     Status:  MEDLINE    
The past 5 years have seen the clear recognition that the administration of chemotherapy to patients with initially unresectable colorectal liver metastases can increase the number of patients who can undergo potentially curative secondary liver resection. Coupled with this, recent data have emerged that show that perioperative chemotherapy confers a disease-free survival advantage over surgery alone in colorectal cancer (CRC) patients with initially resectable liver disease. The purpose of this paper is to build on the existing knowledge and review the issues surrounding the use of chemotherapy +/- targeted agents combined with surgery in the treatment of CRC patients with liver metastases, with a view to providing clinical recommendations. An international panel of 21 experts in colorectal oncology comprising liver surgeons and medical oncologists reviewed the available evidence. In a major change to clinical practice, the panel's recommendation was that the majority of patients with CRC liver metastases should be treated up front with chemotherapy, irrespective of the initial resectability status of their metastases.
B Nordlinger; E Van Cutsem; T Gruenberger; B Glimelius; G Poston; P Rougier; A Sobrero; M Ychou; ;
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Publication Detail:
Type:  Consensus Development Conference; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-19
Journal Detail:
Title:  Annals of oncology : official journal of the European Society for Medical Oncology / ESMO     Volume:  20     ISSN:  1569-8041     ISO Abbreviation:  Ann. Oncol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-07-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9007735     Medline TA:  Ann Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  985-92     Citation Subset:  IM    
Department of Digestive Surgery, Ambroise Paré Hospital, Boulogne, France.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*,  adverse effects
Colorectal Neoplasms / pathology*
Combined Modality Therapy
Drug-Induced Liver Injury
Liver Neoplasms / drug therapy*,  secondary,  surgery*
Neoadjuvant Therapy
Alfredo Carrato / ; Jy-Ming Chiang / ; Bernard De Hemptinne / ; Alfredo Falcone / ; Joan Figueras / ; Jean-Francois Gigot / ; Vassilis Georgoulias / ; Felice Giuliante / ; Rob Glynne-Jones / ; Claus-Henning Köhne / ; Dimitris Papamichael / ; Graeme Poston / ; Carmelo Pozzo / ; Josep Tabernero / ; Harpreet Wasan / ; Richard Wilson /

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