Document Detail


Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2::Luc knock-in mice under two meals per day feeding.
MedLine Citation:
PMID:  20847299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the circadian liver clock is entrained by the feeding cycle, factors such as food volume and starvation interval are poorly understood. Per2::Luc knock-in mice were given two meals per day with different food volume sizes and/or with different intervals of starvation between two mealtimes with the total food volume per day fixed at 3.6 g (80 food pellets, ∼75% of free feeding) per mouse. The bioluminescence rhythm in the liver produced a unimodal peak but not bimodal peak under the regimen of two meals per day over 14-15 days. Peak Per2 expression occurred concurrently with the mealtime of the larger food volume, when the first and second meal were given as different food volume ratios under a 12 h feeding interval. When an equal volume of food was given under different starvation interval (8 h:16 h), the peak of the Per2 rhythm was close to peak by mealtime after long starvation (16 h). When food volumes for each mealtime were changed under 8 h:16 h, the peak rhythm was influenced by combined factors of food volume and starvation interval. Food intake after the 16-h starvation caused a significant increase in liver Per2, Dec1, and Bmal1 gene expression compared with food intake after the 8-h starvation with 8 h:16 h feeding intervals. In conclusion, the present results clearly demonstrate that food-induced entrainment of the liver clock is dependent on both food volume and the starvation interval between two meals. Therefore, normal feeding habits may help to maintain normal clock function in the liver organ.
Authors:
Akiko Hirao; Hiroki Nagahama; Takuma Tsuboi; Mizuho Hirao; Yu Tahara; Shigenobu Shibata
Related Documents :
9160399 - A cellular approach to the study of complex natural behavior patterns in the ragged sea...
9748089 - Time-course studies on plasma glucose, insulin, and cortisol in sea bass (dicentrarchus...
16556929 - Food chaining: a systematic approach for the treatment of children with feeding aversion.
8994899 - Feed intake pattern during lactation and subsequent reproductive performance of sows.
12507609 - The effect of feeding frequency on consumption of food, absorption efficiency, and gona...
18671989 - Effects of facial lobectomy on goldfish feeding behavior.
21295729 - Protecting animal and human health and the nation's food supply through veterinary diag...
18494319 - Successful hatching from eggs carried by females and naturally removed from incubant ma...
6602559 - Dietary lead intake of preschool children.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-16
Journal Detail:
Title:  American journal of physiology. Gastrointestinal and liver physiology     Volume:  299     ISSN:  1522-1547     ISO Abbreviation:  Am. J. Physiol. Gastrointest. Liver Physiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901227     Medline TA:  Am J Physiol Gastrointest Liver Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  G1045-53     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Biological Clocks / genetics
Body Weight / genetics
Circadian Rhythm / genetics*
Eating / genetics*
Feeding Behavior / physiology*
Liver / metabolism*
Male
Mice
Mice, Transgenic
Period Circadian Proteins / genetics*
Reverse Transcriptase Polymerase Chain Reaction
Starvation / genetics*,  metabolism
Chemical
Reg. No./Substance:
0/Per2 protein, mouse; 0/Period Circadian Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lipopolysaccharide binding protein inhibitory peptide protects against acetaminophen-induced hepatot...
Next Document:  Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and...