Document Detail

Combination of sitaxentan and tadalafil for idiopathic pulmonary arterial hypertension following relapse on bosentan.
MedLine Citation:
PMID:  19171388     Owner:  NLM     Status:  MEDLINE    
Sitaxentan, a highly-selective endothelin receptor antagonist (ETRA) and bosentan a non-selective ETRA are both approved for the treatment of idiopathic pulmonary arterial hypertension (iPAH). Sildenafil is a phosphodiesterase-5 (PDE-5) inhibitor used in the treatment of iPAH. Tadalafil is a long acting PDE-5 inhibitor largely unexplored for the treatment of iPAH. Following failure of monotherapy combination therapy with an ETRA and a PDE-5 inhibitor is often used, a frequently used combination being bosentan with sildenafil. We report our clinical experience in three patients with iPAH treated with a combination of sitaxentan and tadalafil, who previously discontinued bosentan. There was sustained symptomatic and haemodynamic improvement in all three patients treated with the combination. No adverse effect related to the combination treatment was noted. Sitaxentan and tadalafil, both being once a day treatments, can also possibly increase compliance.
S Faruqi; H Fathi; A H Morice
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Publication Detail:
Type:  Case Reports; Letter     Date:  2009-01-27
Journal Detail:
Title:  International journal of cardiology     Volume:  144     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-02-18     Revised Date:  2013-06-18    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e43-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2008 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Carbolines / therapeutic use*
Drug Therapy, Combination
Hypertension, Pulmonary / drug therapy*,  physiopathology
Isoxazoles / therapeutic use*
Middle Aged
Receptors, Endothelin / antagonists & inhibitors
Sulfonamides / therapeutic use*
Thiophenes / therapeutic use*
Treatment Outcome
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Antihypertensive Agents; 0/Carbolines; 0/Isoxazoles; 0/Receptors, Endothelin; 0/Sulfonamides; 0/Thiophenes; 0/Vasodilator Agents; 0/sitaxsentan; 0/tadalafil; Q326023R30/bosentan

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