| Combination of rod and cone inputs in parasol ganglion cells of the magnocellular pathway. | |
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MedLine Citation:
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PMID: 20884499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study investigates how rod and cone inputs are combined in the magnocellular (MC) pathway in the mesopic luminance range, when both rods and cones are active. Responses of parafoveal MC ganglion cells from macaque retina were measured as a function of temporal frequency (0.62-20 Hz) or contrast (0.05-0.55) at mesopic light levels (0.2, 2, 20, and 200 td). Stimuli were of three modulation types: (1) isolated rod stimuli (only rod signals were modulated), (2) isolated cone stimuli (only cone luminance signals from long- and middle-wavelength sensitive cones were modulated), and (3) combined rod and cone stimuli (both rod and cone luminance signals were modulated in phase, as with conventional stimuli). The results showed that under mesopic conditions, the relative rod and cone inputs to the MC cells varied with light level and they are combined linearly prior to saturation. Further, rod contrast gain is relatively stable over the mesopic range while cone contrast gain increased with light level. Finally, the measured rod and cone inputs are consistent with the measured human temporal contrast sensitivity functions under comparable stimulation conditions. |
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Authors:
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Dingcai Cao; Barry B Lee; Hao Sun |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-03 |
Journal Detail:
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Title: Journal of vision Volume: 10 ISSN: 1534-7362 ISO Abbreviation: J Vis Publication Date: 2010 |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-03-17 Revised Date: 2012-03-19 |
Medline Journal Info:
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Nlm Unique ID: 101147197 Medline TA: J Vis Country: United States |
Other Details:
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Languages: eng Pagination: 4 Citation Subset: IM |
Affiliation:
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Sections of Surgical Research and Ophthalmology and Visual Science, Department of Surgery, University of Chicago, Chicago, IL, USA. d-cao@uchicago.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Sensitivity / physiology* Macaca Photic Stimulation Retinal Cone Photoreceptor Cells / physiology* Retinal Ganglion Cells / physiology* Retinal Rod Photoreceptor Cells / physiology* Sensory Thresholds / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY013112-08/EY/NEI NIH HHS; R01 EY019651-01A1/EY/NEI NIH HHS; R01EY013112/EY/NEI NIH HHS; R01EY019651/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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