| Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. | |
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MedLine Citation:
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PMID: 21274875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONCLUSION: Our findings indicate that the addition of RA to UDCA reduces the bile salt pool size and liver fibrosis and might be an effective supplemental therapy with UDCA for cholestatic diseases. |
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Authors:
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Hongwei He; Albert Mennone; James L Boyer; Shi-Ying Cai |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-12-10 |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 53 ISSN: 1527-3350 ISO Abbreviation: Hepatology Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-28 Completed Date: 2011-03-18 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: United States |
Other Details:
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Languages: eng Pagination: 548-57 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Association for the Study of Liver Diseases. |
Affiliation:
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Yale Liver Center, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / metabolism Bile Ducts / surgery Cell Proliferation Cells, Cultured Cholestasis, Intrahepatic / metabolism, pathology*, prevention & control* Cholesterol 7-alpha-Hydroxylase / metabolism Collagen Type I / metabolism Disease Models, Animal Hepatocytes / drug effects*, metabolism, pathology* Humans Ligation Liver / drug effects, metabolism, pathology Male Matrix Metalloproteinase 2 / metabolism Rats Rats, Sprague-Dawley Smad2 Protein / metabolism Tretinoin / pharmacology, therapeutic use* Ursodeoxycholic Acid / pharmacology, therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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DK25636/DK/NIDDK NIH HHS; DK34989/DK/NIDDK NIH HHS; P30 DK034989/DK/NIDDK NIH HHS; P30 DK034989-277466/DK/NIDDK NIH HHS; R37 DK025636-33/DK/NIDDK NIH HHS; R37 DK025636-35/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Collagen Type I; 0/Smad2 Protein; 0/collagen type I, alpha 1 chain; 128-13-2/Ursodeoxycholic Acid; 302-79-4/Tretinoin; EC 1.14.13.17/CYP7A1 protein, human; EC 1.14.13.17/CYP7A1 protein, rat; EC 1.14.13.17/Cholesterol 7-alpha-Hydroxylase; EC 3.4.24.24/Matrix Metalloproteinase 2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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