Document Detail

Combination of pulse therapy with terbinafine tablets and topical terbinafine cream for the treatment of dermatophyte onychomycosis: a pilot study.
MedLine Citation:
PMID:  17073989     Owner:  NLM     Status:  MEDLINE    
We performed a pilot study to assess the safety and efficacy of pulse therapy with terbinafine tablets in 66 patients with dermatophyte onychomycosis. One pulse consisted of oral terbinafine tablets (500 mg/day) given for 1 week followed by a 3-week interval. Topical 1% terbinafine cream was applied daily. The number of pulses was determined by the extent of improvement in the affected nails and by the patient's requests, up to a maximum of six pulses. Efficacy was assessed based on both clinical and mycological examinations 1 year after treatment initiation. We observed a complete cure in 51 patients (77.3%), marked improvement in five patients (7.6%), improvement in five patients (7.6%) and slight improvement in one patient (1.5%). Four patients (6.0%) showed no change. In the patients who were completely cured, the average number of pulses used was 3.7 +/- 1.4 pulses and the treatment duration was 3.3 +/- 1.6 months. Nine patients experienced adverse effects, consisting of gastrointestinal disturbance (eight patients) and drug-induced eruption (one patient). There were no abnormal findings in the laboratory tests, including liver function tests. In summary, terbinafine pulse therapy in combination with topical application of terbinafine cream appeared safe and effective in this pilot study.
Naomi Nakano; Masataro Hiruma; Yumi Shiraki; Xuejun Chen; Sarawan Porgpermdee; Shigaku Ikeda
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of dermatology     Volume:  33     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-31     Completed Date:  2007-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  753-8     Citation Subset:  IM    
Department of Dermatology, Juntendo University School of Medicine, Juntendo, Tokyo, Japan.
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MeSH Terms
Administration, Cutaneous
Administration, Oral
Aged, 80 and over
Antifungal Agents / administration & dosage*
Arthrodermataceae / isolation & purification
Foot Dermatoses / drug therapy*,  microbiology,  pathology
Hand Dermatoses / drug therapy*,  microbiology,  pathology
Middle Aged
Naphthalenes / administration & dosage*
Onychomycosis / drug therapy*,  microbiology,  pathology
Pilot Projects
Pulse Therapy, Drug
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Antifungal Agents; 0/Naphthalenes; 91161-71-6/terbinafine

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