Document Detail

Combination of noninvasive brain stimulation with pharmacotherapy.
MedLine Citation:
PMID:  21158538     Owner:  NLM     Status:  In-Process    
Noninvasive brain stimulation (NIBS) techniques are being increasingly investigated as a therapeutic approach for neuropsychiatric disorders. One method is to combine NIBS with pharmacotherapy to enhance the clinical effects or avoid an increase in drug dosages to decrease the incidence of side effects. However, few studies to date have investigated the relative and combined efficacy of NIBS with pharmacotherapy. Based on a literature review of previous studies and meta-analyses for major depression, we identified four randomized, controlled trials that tested the combination of NIBS with a new drug and two trials that directly compared NIBS versus pharmacotherapy. There was no study designed to address the relative efficacy of each intervention against placebo and against combined therapy. We discuss the methods and rationale of NIBS-pharmacotherapy trials, addressing some methodological aspects, including factorial design, recruitment, blinding, blinding assessment, placebo effect and quantitative aspects, such as power analysis, statistics and interaction effects. Our review of the methodology underlying NIBS-drug trials provides insights for the further clinical research development of NIBS in major depression.
Andre Russowsky Brunoni; Clarissa Valim; Felipe Fregni
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Expert review of medical devices     Volume:  8     ISSN:  1745-2422     ISO Abbreviation:  Expert Rev Med Devices     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230445     Medline TA:  Expert Rev Med Devices     Country:  England    
Other Details:
Languages:  eng     Pagination:  31-9     Citation Subset:  IM    
Department of Neurosciences and Behavior, Institute of Psychology, University of São Paulo, Brazil.
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MeSH Terms
Grant Support
1 UL1 RR02578-01/RR/NCRR NIH HHS

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