Document Detail


Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model.
MedLine Citation:
PMID:  21152526     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Studies using this micro-system demonstrated significant morphological differences between alveolar epithelial cells (transformed human alveolar epithelial cell line, A549 and primary murine alveolar epithelial cells, AECs) exposed to combination of solid mechanical and surface-tension stresses (cyclic propagation of air-liquid interface and wall stretch) compared to cell populations exposed solely to cyclic stretch. We have also measured significant differences in both cell death and cell detachment rates in cell monolayers experiencing combination of stresses. This research describes new tools for studying the combined effects of fluid mechanical and solid mechanical stress on alveolar cells. It also highlights the role that surface tension forces may play in the development of clinical pathology, especially under conditions of surfactant dysfunction. The results support the need for further research and improved understanding on techniques to reduce and eliminate fluid stresses in clinical settings.
Authors:
Nicholas J Douville; Parsa Zamankhan; Yi-Chung Tung; Ran Li; Benjamin L Vaughan; Cheng-Feng Tai; Joshua White; Paul J Christensen; James B Grotberg; Shuichi Takayama
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Publication Detail:
Type:  Journal Article     Date:  2010-12-09
Journal Detail:
Title:  Lab on a chip     Volume:  11     ISSN:  1473-0189     ISO Abbreviation:  Lab Chip     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  609-19     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, University of Michigan, 2200 Bonisteel Blvd., Ann Arbor, MI 48109, USA. takayama@umich.edu.
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