Document Detail


Combination of factor V Leiden and MTHFR mutations in myocardial infarction.
MedLine Citation:
PMID:  22750768     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Identifying patients who are at high risk of suffering myocardial infarction can be done by determining risk factors or by the adoption of molecular genetic testing for inherited thrombophilia. We report a case of myocardial infarction at a young age. The patient complained of dyspnea (stage III) and a burning pain of severe intensity that radiated to the left retrosternal side, but was not associated with palpitations or diaphoresis. A number of biochemical parameters were normal except for an elevated creatinine phosphokinase (CPK) level. Genetic testing revealed the subject to be heterozygous for both the factor V leiden and MTHFR C677T polymorphisms. The combination of these two mutations may be a high risk factor for myocardial infarction. Genetic screening for inherited thrombophilia in young patients, especially in the presence of a common risk factor, may be useful for primary thromboprophylaxis and in asymptomatic relatives of patients.
Authors:
Najiba Fekih-Mrissa; Dhouha Berredjeb-Benslama; Abdeddayem Haggui; Habib Haouala; Nasreddine Gritli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-1
Journal Detail:
Title:  Annals of Saudi medicine     Volume:  -     ISSN:  0975-4466     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507355     Medline TA:  Ann Saudi Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-2     Citation Subset:  -    
Affiliation:
Najiba Fekih-Mrissa, Laboratory of Molecular Biology, Department of Hematology, Military Hospital, 1008 Mont Fleury, Tunis, Tunisia, T: +21622510488 fnajiba@yahoo.fr.
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