| Combination of erythritol and fructose increases gastrointestinal symptoms in healthy adults. | |
| | |
MedLine Citation:
|
PMID: 22118754 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Consumption of a large amount of dietary fructose induces gastrointestinal intolerance, and glucose has been known as an enhancer of fructose absorption. Erythritol is a nonglycemic sugar alcohol, and it has been suggested that erythritol is absorbed paracellularly. It was hypothesized that paracellular absorption of erythritol could also enhance paracellular absorption of fructose in healthy adults. This is one of the proposed pathways for how additional glucose enhances the absorption of fructose. Thirty-seven nondiabetic, healthy adults participated in a randomized, double-masked, controlled crossover study. After an overnight fast, participants consumed beverages containing either 50 g fructose and 50 g glucose, 50 g fructose and 33.3 g erythritol (an equimolar concentration of fructose), or 50 g fructose alone. Breath hydrogen response was determined for 8 hours postprandially. Gastrointestinal intolerance symptoms and the number and consistency of bowel movements were recorded for 24 hours postprandially. The breath hydrogen area under the curve (AUC) of the fructose and erythritol beverage was 2 times the AUC of the fructose beverage and 8.75 times the AUC of the fructose and glucose beverage (P < .001, respectively). Compared with fructose and glucose beverage and fructose alone, frequency of watery stools increased (P < .05) and gastrointestinal tolerance worsened (P < .05) when participants consumed fructose and erythritol. These data suggest that coingestion of equimolar concentrations of fructose and erythritol increased carbohydrate malabsorption. |
| | |
Authors:
|
Yeonsoo Kim; Sonhee C Park; Bryan W Wolf; Steven R Hertzler |
Related Documents
:
|
16556844 - Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell r... 17491654 - The role of regulatory t cell defects in type i diabetes and the potential of these cel... 20682694 - Insulin transactivator mafa regulates intrathymic expression of insulin and affects sus... 8972684 - Diabetic animal models. 12705484 - Lipoprotein (a) and glycaemic control in pakistani subjects with diabetes mellitus. 9051204 - Plasma lipoproteins and incidence of non-insulin-dependent diabetes mellitus in pima in... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nutrition research (New York, N.Y.) Volume: 31 ISSN: 1879-0739 ISO Abbreviation: Nutr Res Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8303331 Medline TA: Nutr Res Country: United States |
Other Details:
|
Languages: eng Pagination: 836-41 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Louisiana Tech University, School of Human Ecology, Ruston, LA 71272, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selenium deficiency is associated with insulin resistance in patients with hepatitis C virus-related...
Next Document: Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome rece...