Document Detail

Combination of electrocardiographic and echocardiographic information identifies individuals prone to a progressive increase in left ventricular mass over 5 years.
MedLine Citation:
PMID:  19262408     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We assessed whether the relationship between electrocardiographic and echocardiographic information on left ventricular hypertrophy predicts the development of left ventricular mass over 5 years. METHODS: Linear regression analyses between various electrocardiographic indices of left ventricular hypertrophy and left ventricular mass (echocardiography) indexed to height2.7 (LVMI(ht)) was performed in 1488 individuals in each gender subgroup (45-79 years, 841 female, exclusion of intraventricular conduction defects) from the population-based, longitudinal 'Study of Health in Pomerania'. A parameter expressing the difference between observed ECG indices of left ventricular hypertrophy and ECG indices predicted on the basis of echocardiographic readings was calculated in each individual at the baseline visit. RESULTS: In individuals with complete echocardiographic data at baseline and 5-year-follow-up (n = 1031, exclusion of aortic valve disease), LVMI(ht) at 5-year-follow-up was significantly correlated with the parameter derived from the Cornell product (P < 0.001), the Cornell voltage (P < 0.001), the Gubner-Ungerleider-product (P < 0.001), the Gubner-Ungerleider-voltage (P < 0.001), Lewis voltage (P < 0.001) and aVL voltage (P < 0.001), but not with Sokolow-Lyon-index-derived parameters. LVMI(ht) at baseline did not significantly correlate with any of these ECG-derived parameters. In female individuals with Cornell products higher than expected based on echocardiographic readings, left ventricular mass increased from 162.3 +/- 2.6 g to 180.5 +/- 2.8 g (males: 213.1 +/- 3.7 g to 236.3 +/- 4.2 g), whereas left ventricular mass increased only from 161.8 +/- 2.5 g to 173.5 +/- 2.8 g (males: 209.7 +/- 3.7 g to 215.8 +/- 3.7 g) in individuals with lower than expected Cornell products (P < 0.001). CONCLUSION: The relationship of electrocardiographic and echocardiographic information on left ventricular mass may identify individuals at risk for developing progressive increase in left ventricular mass.
Thorsten Reffelmann; Marcus Dörr; Henry Völzke; Jan Kors; Jörg Ruppert; Daniel Robinson; Stephan B Felix
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  27     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  861-8     Citation Subset:  IM    
aKlinik und Poliklinik für Innere Medizin B, Universitätsklinikum, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Germany.
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MeSH Terms
Disease Progression
Follow-Up Studies
Hypertrophy, Left Ventricular / diagnosis*
Linear Models
Middle Aged
Risk Factors

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