| Combination chemotherapy with doxorubicin, dacarbazine, and ifosfamide in advanced adult soft tissue sarcoma. Canadian Sarcoma Group--National Cancer Institute of Canada Clinical Trials Group. | |
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MedLine Citation:
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PMID: 2778839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty-three adult patients with locally advanced or metastatic soft tissue sarcoma entered a pilot study of combination chemotherapy comprising 50 mg of doxorubicin/m2 by intravenous bolus, 850 mg of dacarbazine/m2 by 1-hour infusion, and 5 g of ifosfamide/m2 by 24-hour infusion with mesna uroprotection. The overall response rate in 40 assessable patients was 25% with two complete remissions. Twenty-four episodes of infection occurred in 148 courses (16%). These infections were usually associated with neutropenia (granulocyte count less than 0.5 X 10(9)/L), which occurred in 70% of the courses. These results do not differ from those elicited by each agent alone, and may reflect inadequacies of dose intensity or scheduling, or evaluation in a study population with adverse prognostic factors. |
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Authors:
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V Bramwell; I Quirt; D Warr; S Verma; V Young; M Knowling; E Eisenhauer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the National Cancer Institute Volume: 81 ISSN: 0027-8874 ISO Abbreviation: J. Natl. Cancer Inst. Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1989-10-20 Completed Date: 1989-10-20 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 7503089 Medline TA: J Natl Cancer Inst Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1496-9 Citation Subset: IM |
Affiliation:
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London Regional Cancer Centre, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols / adverse effects, therapeutic use* Dacarbazine / administration & dosage*, adverse effects Doxorubicin / administration & dosage*, adverse effects Female Follow-Up Studies Humans Ifosfamide / administration & dosage*, adverse effects Infusions, Intravenous Male Middle Aged Pilot Projects Remission Induction Sarcoma / drug therapy*, secondary Soft Tissue Neoplasms / drug therapy* |
| Chemical | |
Reg. No./Substance:
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23214-92-8/Doxorubicin; 3778-73-2/Ifosfamide; 4342-03-4/Dacarbazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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