Document Detail

Combination chemotherapy with continuous infusion vinblastine and peptichemio for patients with advanced metastatic breast cancer.
MedLine Citation:
PMID:  7180829     Owner:  NLM     Status:  MEDLINE    
Forty patients with metastatic breast cancer were treated with a combination of continuous 5-day infusion vinblastine and peptichemio. All patients had received prior therapy with 5-fluorouracil, adriamycin, cyclophosphamide and methotrexate. Vinblastine was given at a dose of 1.2 mg/m2/day for 5 days. Following completion of the 5-day infusion vinblastine, peptichemio was given as a rapid I.V. injection at a dose of 60 mg/m2. Ten partial responses (30%) were observed among the 33 evaluable patients with a median time to treatment failure of 6 months. Myelosuppression, predominantly granulocytopenia, was the major toxicity resulting from this combination. The response rate of this combination is not better than that observed with continuous 5-day infusion vinblastine alone.
H Y Yap; G R Blumenschein; G N Hortobagyi; A U Buzdar; F C Schell; G P Bodey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  5     ISSN:  0277-3732     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  511-4     Citation Subset:  IM    
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MeSH Terms
Agranulocytosis / chemically induced
Breast Neoplasms / drug therapy*
Drug Therapy, Combination
Infusions, Parenteral
Melphalan / analogs & derivatives*
Middle Aged
Peptichemio / administration & dosage*,  adverse effects
Vinblastine / administration & dosage*,  adverse effects
Reg. No./Substance:
148-82-3/Melphalan; 865-21-4/Vinblastine; 9076-25-9/Peptichemio

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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