| Combination chemotherapy of serine protease inhibitor nafamostat mesilate with oxaliplatin targeting NF-kappaB activation for pancreatic cancer. | |
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MedLine Citation:
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PMID: 23348695 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this study, we assessed if nafamostat mesilate may enhance anti-tumor effects of oxaliplatin on Panc-1 cells and pancreatic cancer mouse model. In combination treatment with nafamostat mesilate and oxaliplatin, NF-κB activation was inhibited by suppressing IκBα phosphorylation, and caspase-8-mediated apoptosis was more prominent than that treated with oxaliplatin alone, both in vitro and in vivo. Nafamostat mesilate reduced proliferation rate of Panc-1 cells as compared with oxaliplatin alone in vitro and enhanced oxaliplatin-induced tumor growth inhibition in vivo. Combination chemotherapy using nafamostat mesilate and oxaliplatin induces synergistic cytotoxicity in pancreatic cancer and could be a novel strategy for treatment. |
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Authors:
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Takeshi Gocho; Tadashi Uwagawa; Kenei Furukawa; Koichiro Haruki; Yuki Fujiwara; Ryota Iwase; Takeyuki Misawa; Toya Ohashi; Katsuhiko Yanaga |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-21 |
Journal Detail:
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Title: Cancer letters Volume: - ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2013. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan. Electronic address: gocho@jikei.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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