Document Detail

Combination chemotherapy of metastatic breast cancer: a randomized trial comparing the use of adriamycin to that of Vinblastine.
MedLine Citation:
PMID:  383254     Owner:  NLM     Status:  MEDLINE    
Two regimens of chemotherapy for metastatic breast cancer were compared in a randomized controlled fashion. Regimen 1 consisted of cyclophosphamide, vinblastine, methotrexate and 5-fluorouracil (CVMF). Regimen 2 consisted of cyclophosphamide, adriamycin, methotrexate and 5-fluorouracil (CAMF). The patient population consisted of both black and white postmenopausal females who had not received any prior chemotherapy. Objective responses were observed in 25/57 patients treated with CVMF and in 28/51 patients treated with CAMF. Neither race nor choice of chemotherapeutic regimen affected prognosis, although there were differences in the pattern of metastatic involvement between the two racial groups. The median duration of survival of patients who responded to therapy has not yet been reached but will be in excess of 12 months.
W R Bezwoda; N G de Moor; D Derman; M Lange; R Saner; R Dando
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Cancer     Volume:  44     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  392-7     Citation Subset:  AIM; IM    
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MeSH Terms
Antineoplastic Agents / administration & dosage*,  adverse effects
Bone Marrow / drug effects
Breast Neoplasms / drug therapy*,  secondary
Clinical Trials as Topic
Doxorubicin / administration & dosage*
Drug Therapy, Combination
Middle Aged
Remission, Spontaneous
Vinblastine / administration & dosage*
Reg. No./Substance:
0/Antineoplastic Agents; 23214-92-8/Doxorubicin; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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