| Combination chemotherapy of metastatic breast cancer: a randomized trial comparing the use of adriamycin to that of Vinblastine. | |
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MedLine Citation:
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PMID: 383254 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two regimens of chemotherapy for metastatic breast cancer were compared in a randomized controlled fashion. Regimen 1 consisted of cyclophosphamide, vinblastine, methotrexate and 5-fluorouracil (CVMF). Regimen 2 consisted of cyclophosphamide, adriamycin, methotrexate and 5-fluorouracil (CAMF). The patient population consisted of both black and white postmenopausal females who had not received any prior chemotherapy. Objective responses were observed in 25/57 patients treated with CVMF and in 28/51 patients treated with CAMF. Neither race nor choice of chemotherapeutic regimen affected prognosis, although there were differences in the pattern of metastatic involvement between the two racial groups. The median duration of survival of patients who responded to therapy has not yet been reached but will be in excess of 12 months. |
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Authors:
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W R Bezwoda; N G de Moor; D Derman; M Lange; R Saner; R Dando |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Cancer Volume: 44 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1979 Aug |
Date Detail:
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Created Date: 1979-11-21 Completed Date: 1979-11-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 392-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Agents / administration & dosage*, adverse effects Bone Marrow / drug effects Breast Neoplasms / drug therapy*, secondary Clinical Trials as Topic Doxorubicin / administration & dosage* Drug Therapy, Combination Female Humans Middle Aged Remission, Spontaneous Vinblastine / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 23214-92-8/Doxorubicin; 865-21-4/Vinblastine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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