Document Detail


Combination chemotherapy for Hodgkin's lymphoma during pregnancy: favorable outcome for mother and child.
MedLine Citation:
PMID:  20666963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of malignant neoplasms in pregnant women is rising dramatically. The management of such cases poses unusual medical and ethical challenges, particularly in hematological malignancies, when potentially teratogenic chemotherapy is indicated. We report a case of stage IIA nodular sclerosis Hodgkin's lymphoma (HL), diagnosed in a 24-year-old woman at 18 weeks of gestation. Individualized combination chemotherapy according to etoposide-vinblastine-doxorubicin (EVA) regimen was administered, resulting in effective local control of the disease and improvement in the patient's general condition. At the 36th week of pregnancy, the patient delivered a healthy female infant by elective cesarian section. Four weeks later, bleomycin-dacarbazine-doxorubicin-vinblastine (ABVD) chemotherapy was commenced, which provided complete remission after five cycles. Individualized chemotherapy for HL according to EVA regimen during the second and third trimesters of pregnancy, with early cesarian delivery, followed by ABVD regimen, provided a positive outcome both for the mother and her child. This strategy may be considered as an alternative for the treatment of HL in pregnancy, and deserves further clinical assessment.
Authors:
Dariusz Sagan; Andrzej Semczuk; Elzbieta Lampka
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  36     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-29     Completed Date:  2010-11-04     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  882-6     Citation Subset:  IM    
Affiliation:
Department of Thoracic Surgery, Medical University of Lublin, Lublin, Poland. dariusz.sagan@am.lublin.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Antineoplastic Combined Chemotherapy Protocols*
Bleomycin
Dacarbazine
Disease-Free Survival
Doxorubicin
Etoposide
Female
Hodgkin Disease / drug therapy*
Humans
Pregnancy
Pregnancy Complications, Neoplastic / drug therapy*
Treatment Outcome
Vinblastine
Chemical
Reg. No./Substance:
11056-06-7/Bleomycin; 23214-92-8/Doxorubicin; 33419-42-0/Etoposide; 4342-03-4/Dacarbazine; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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