| Combination of branched-chain amino acid and angiotensin‑converting enzyme inhibitor improves liver fibrosis progression in patients with cirrhosis. | |
| | |
MedLine Citation:
|
PMID: 22089860 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
An effective therapeutic strategy for suppressing liver fibrosis should improve the overall prognosis of patients with chronic liver diseases. Although enormous efforts are ongoing to develop anti-fibrotic agents, no drugs have yet been approved as anti-fibrotic agents for humans. Insulin resistance (IR) is reportedly involved in the progression of liver fibrosis. The aim of the present study was to evaluate the effect of combination treatment with a clinically used branched-chain amino acid (BCAA) and an angiotensin-converting enzyme inhibitor (ACE-I) on several fibrotic indices in patients with liver cirrhosis under the condition of IR. BCAA granules (Livact; 12 g/day) and/or ACE-I (perindopril; 4 mg/day) were administered, and several indices were analyzed. A 48-month follow-up revealed that the combination treatment with BCAA and ACE-I markedly improved the progression of serum fibrosis markers, whereas single treatment with either BCAA or ACE-I did not exert these inhibitory effects. The plasma level of transforming growth factor-β was significantly attenuated almost in parallel with the suppression of serum fibrosis markers. Furthermore, the combined treatment with BCAA and ACE-I improved the serum albumin level and IR, which was evaluated using the homeostasis model assessment method for IR. Taken together, since both BCAA and ACE-I are widely used with safety in clinical practice, these results indicate that this combination therapy may represent a potential new future strategy against liver fibrosis development in patients with liver cirrhosis under the condition of IR. |
| | |
Authors:
|
Hitoshi Yoshiji; Ryuichi Noguchi; Yasuhide Ikenaka; Kosuke Kaji; Yosuke Aihara; Akitoshi Douhara; Junichi Yamao; Masahisa Toyohara; Akira Mitoro; Masayoshi Sawai; Motoyuki Yoshida; Chie Morioka; Masao Fujimoto; Masahito Uemura; Hiroshi Fukui |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-15 |
Journal Detail:
|
Title: Molecular medicine reports Volume: - ISSN: 1791-3004 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101475259 Medline TA: Mol Med Report Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
The Third Department of Internal Medicine, Nara Medical University, Nara 634-8522, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The copper-inducible ComR (YcfQ) repressor regulates expression of ComC (YcfR), which affects copper...
Next Document: Experimental and theoretical investigations of isomerization reactions of ionized acetone and its di...