| Combination of apolipoprotein E2 and lipoprotein lipase heterozygosity causes severe hypertriglyceridemia during pregnancy. | |
| | |
MedLine Citation:
|
PMID: 16142021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Pregnancy is a physiological condition where plasma triglyceride levels are moderately increased. This results from raised synthesis of very-low-density lipoproteins (VLDL) in response to elevated estrogen levels. The occurrence of marked hypertriglyceridemia (HTG) is rare and may result from combination of heterozygote mutation in the lipoprotein lipase (LPL) gene and apolipoprotein E2 isoform, as reported in this case. This observation illustrates the interaction between genetic and environmental factors, since pregnancy may disclose a silent LPL deficiency. The risk of acute pancreatitis threatens both the mother and fetus lives. Early recognition of severe HTG and appropriate management are essential for a successful pregnancy outcome. |
| | |
Authors:
|
S Hiéronimus; P Benlian; P Bayer; A Bongain; A Fredenrich |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Diabetes & metabolism Volume: 31 ISSN: 1262-3636 ISO Abbreviation: Diabetes Metab. Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-09-05 Completed Date: 2005-09-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9607599 Medline TA: Diabetes Metab Country: France |
Other Details:
|
Languages: eng Pagination: 295-7 Citation Subset: IM |
Affiliation:
|
Service d'endocrinologie-médecine de la reproduction, Hôpital l'Archet, Nice, France. Hieronimus.s@chu-nice.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Apolipoprotein E2 Apolipoproteins E / genetics* Female Heterozygote Detection* Humans Hypertriglyceridemia / genetics* Lipoprotein Lipase / genetics* Mutation Pregnancy Pregnancy Complications / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Apolipoprotein E2; 0/Apolipoproteins E; EC 3.1.1.34/Lipoprotein Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determination of HbA1c concentrations in patients with acute myocardial infarction: comparison of th...
Next Document: Is capillary ketone determination useful in clinical practice? In which circumstances?