Document Detail

Combination antiretroviral therapy and incidence of AIDS-related malignancies.
MedLine Citation:
PMID:  10430214     Owner:  NLM     Status:  MEDLINE    
We evaluated recent trends in the incidence of AIDS-related malignancies using Cox proportional hazards analysis in 622 men with well-characterized dates of HIV seroconversion in the San Francisco City Clinic cohort. By the end of 1996, 182 men had been diagnosed with Kaposi's sarcoma (KS), and 45 men had been diagnosed with lymphoma. The incidence of KS dropped from 3.5 to 0 per 100 person-years between 1993 through 1995 and 1996 (p = .07), whereas lymphoma incidence remained stable between these periods (1.4-1.8, p = .2). Combination antiretroviral therapy increased from 13% to 23% in 1993 through 1995 to 49% in 1996 and 79% in 1997. The decline in KS cannot be explained by earlier declines in HIV incidence, and concurrent increases in antiretroviral therapy suggests that control of viral replication may lead to a direct or indirect effect on KS pathogenesis. Failure to see such a trend for AIDS-related lymphoma may reflect inadequate follow-up time after widespread use of therapy or a need to treat earlier in the course of HIV infection to prevent HIV-associated lymphomagenesis.
S P Buchbinder; S D Holmberg; S Scheer; G Colfax; P O'Malley; E Vittinghoff
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  21 Suppl 1     ISSN:  1525-4135     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-08-24     Completed Date:  1999-08-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S23-6     Citation Subset:  IM; X    
HIV Research Section, San Francisco Department of Public Health, California, USA.
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MeSH Terms
AIDS-Related Opportunistic Infections / epidemiology*
Anti-HIV Agents* / administration & dosage
Central Nervous System Neoplasms / epidemiology
Drug Therapy, Combination
Lymphoma / epidemiology*
Lymphoma, AIDS-Related / epidemiology
Lymphoma, Non-Hodgkin / epidemiology
Grant Support
R64/CCU912541//PHS HHS
Reg. No./Substance:
0/Anti-HIV Agents

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