Document Detail

Combination antiplatelet therapy: implications for pharmacists.
MedLine Citation:
PMID:  12482014     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To present two case reports of patients who received suboptimal oral antiplatelet therapy and to review recent changes in national guidelines for management of acute coronary syndromes. DATA SOURCES: Personal observation by the authors, and clinical practice guidelines and related clinical trials of the American Heart Association and the American College of Cardiology. SUMMARY: The American College of Cardiology and the American Heart Association revised the guidelines for administration of antiplatelet and anticoagulant therapy in patients with unstable angina and non-ST-segment elevation myocardial infarction in March 2002. Two cases observed by the authors illustrate the consequences of suboptimal antiplatelet therapy when a combination of two antiplatelet drugs should have been administered. CONCLUSION: Evidence from recent randomized, controlled trials led to changes in the national guidelines for administration of oral antiplatelet therapy in patients with acute coronary syndromes. Pharmacists should be aware of these changes and counsel patients about appropriate administration of antiplatelet drugs.
Robert L Talbert; Sarah A Spinier; Jean M Nappi; Michael B Bottorff
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Pharmaceutical Association (Washington,D.C. : 1996)     Volume:  42     ISSN:  1086-5802     ISO Abbreviation:  J Am Pharm Assoc (Wash)     Publication Date:    2002 Nov-Dec
Date Detail:
Created Date:  2002-12-16     Completed Date:  2003-01-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9601004     Medline TA:  J Am Pharm Assoc (Wash)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  880-3     Citation Subset:  IM    
College of Pharmacy, University of Texas-Austin, USA.
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MeSH Terms
Coronary Artery Disease / drug therapy
Drug Therapy, Combination
Middle Aged
Patient Compliance
Pharmaceutical Services
Platelet Aggregation Inhibitors / administration & dosage*,  adverse effects,  therapeutic use*
Practice Guidelines as Topic
Reg. No./Substance:
0/Platelet Aggregation Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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