Document Detail

Combination anesthesia with ketamine and pentobarbital: a long-term porcine model.
MedLine Citation:
PMID:  10494673     Owner:  NLM     Status:  MEDLINE    
Anesthesia of the pig poses great problems for experimental animal-based research and particularly in shock research. In this study, five mechanically ventilated domestic pigs were given long-term anesthesia with a combination of ketamine plus pentobarbital. Circulatory parameters were recorded every 2 h via an arterial catheter placed in the right common carotid artery, a Swan-Gans thermodilution catheter (7F), that was placed in the pulmonary artery of the right middle-lobe in a wedge position through the external jugular vein, and another catheter in the internal jugular vein for measuring central venous pressure. Moreover, body weight, blood gases, pH, blood cells, electrolytes and serum enzymes were measured. Further serum traits as total protein and glucose and pathological alterations in different organs were recorded. The animals were observed for a period of 96 h and then killed painlessly. It was shown that pigs can survive 96-h anesthesia with the combination of ketamine and pentobarbital. Optimum, carefully controlled anesthesia did not impair the integrity of the regulatory mechanisms of circulation.
C Goldmann; A Ghofrani; B Hafemann; P Fuchs; R Khorram-Seffat; M Afify; W Küpper; N Pallua
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie     Volume:  199     ISSN:  0300-9130     ISO Abbreviation:  Res Exp Med (Berl)     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-11-17     Completed Date:  1999-11-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0324736     Medline TA:  Res Exp Med (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  35-50     Citation Subset:  IM    
Department of Laboratory Animal Research, The Technical University of Aachen, Germany.
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MeSH Terms
Adjuvants, Anesthesia / pharmacology*
Anesthesia, Intravenous / methods*
Anesthetics, Combined / pharmacology*
Anesthetics, Dissociative / pharmacology*
Ketamine / pharmacology*
Monitoring, Physiologic
Pentobarbital / pharmacology*
Time Factors
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Anesthetics, Combined; 0/Anesthetics, Dissociative; 6740-88-1/Ketamine; 76-74-4/Pentobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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