Document Detail


Combination of oral corticosteroids and polidocanol sclerotherapy in the management of infantile hemangiomas.
MedLine Citation:
PMID:  21040124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Infantile hemangiomas (IHs) are the most common benign tumors of infancy and may need to be treated in some cases. Oral corticosteroids are the mainstay of therapy but are not without their attendant side effects.
OBJECTIVES: To evaluate the efficacy of combination therapy with oral corticosteroids and polidocanol sclerotherapy in hemangiomas needing treatment.
PATIENTS AND METHODS: Eight children with IHs were started on oral prednisolone 3 to 4 mg/kg per day and fortnightly sclerotherapy with 3% polidocanol solution. The outcome was evaluated on the basis of color, turgidity of the lesion, ongoing growth, and assessment by parents and physician. Serial photographic records were maintained. The response was graded as excellent, good, poor, or nil. Complications were recorded.
RESULTS: Four male and four female patients presented at a mean age of 4.6 months. The average area of the lesions was 40.6 cm(2) . The mean duration of treatment with steroids at full dose was 8.2 weeks and mean total duration of treatment was 28.6 weeks. Mean number of sclerotherapy sessions required was 4.7. Complications included ischemic necrosis, rebound growth, and ulceration.
CONCLUSION: Combining oral corticosteroids with polidocanol sclerotherapy produced excellent results in the patients treated, with minimal attendant side effects.
Authors:
Chander Grover; Pooja Arora; Ashwini Kedar; Priyanka Pal; Brahmanand Lal
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Publication Detail:
Type:  Journal Article     Date:  2010-10-11
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  36     ISSN:  1524-4725     ISO Abbreviation:  Dermatol Surg     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2030-6     Citation Subset:  IM    
Copyright Information:
© 2010 by the American Society for Dermatologic Surgery, Inc.
Affiliation:
Department of Dermatology, Chacha Nehru Bal Chikitsalaya, New Delhi, India. chandergroverkubba@rediffmail.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adrenal Cortex Hormones / administration & dosage,  therapeutic use*
Combined Modality Therapy
Female
Hemangioma, Capillary / therapy*
Humans
Infant
Male
Polyethylene Glycols / administration & dosage,  therapeutic use*
Prednisolone / administration & dosage,  therapeutic use*
Prospective Studies
Sclerosing Solutions / administration & dosage,  therapeutic use*
Sclerotherapy / methods*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Polyethylene Glycols; 0/Sclerosing Solutions; 50-24-8/Prednisolone; 9002-92-0/polidocanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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