| Combination of genistin and fructooligosaccharides prevents bone loss in ovarian hormone deficiency. | |
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MedLine Citation:
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PMID: 20132047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have reported that soy isoflavones are capable of preventing loss of bone mineral density (BMD) in rats due to ovariectomy. The intestinal microflora is important in rendering soy isoflavones bioavailability by facilitating their conversion to equol. Hence, substances that can modulate the intestinal microflora could affect the bioavailability of isoflavones. The purpose of this study was to examine whether combination of genistin and fructooligosaccharides (FOS), a prebiotic, can enhance the effects of soy isoflavones on bone in ovariectomized (OVX) female rats. Forty-eight 90-day-old female Sprague-Dawley rats were either sham-operated (Sham; one group) or Ovx (three groups) and were placed on dietary treatment for 50 days. The Sham and one Ovx group received a control diet, and the remaining Ovx groups received genistin-rich isoflavones diet (Ovx+G) or genistin-rich isoflavones and FOS diet (Ovx+G+FOS). After 50 days, blood and bone specimens were collected for analysis. The genistin-rich isoflavones diet was able to significantly increase the whole-body, right femur, and fourth lumbar BMD by 1.6%, 1.48%, and 1.3%, respectively in comparison with the Ovx control. The combination of genistin-rich isoflavones diet and 5% FOS further increased whole-body, right femur, and fourth lumbar BMD more compared to the genistin-rich isoflavones diet. Our findings suggest that although a genistin-rich isoflavones diet can increase the BMD in rats with Ovx-induced bone loss, combination of genistin-rich isoflavones and FOS had greater effect in preventing bone loss in this rat model. |
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Authors:
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Shirin Hooshmand; Shanil Juma; Bahram H Arjmandi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medicinal food Volume: 13 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 320-5 Citation Subset: IM |
Affiliation:
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Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, Florida 32306-1493, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Density / drug effects* Bone Density Conservation Agents / pharmacology, therapeutic use* Bone and Bones / drug effects, metabolism Drug Therapy, Combination Estrogens / deficiency Female Intestines / microbiology Isoflavones / pharmacology, therapeutic use* Oligosaccharides / pharmacology, therapeutic use* Osteolysis / metabolism, prevention & control* Osteoporosis / drug therapy*, metabolism Ovariectomy Ovary Phytoestrogens / pharmacology, therapeutic use Phytotherapy Plant Extracts / pharmacology, therapeutic use* Prebiotics Rats Soybeans / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Bone Density Conservation Agents; 0/Estrogens; 0/Isoflavones; 0/Oligosaccharides; 0/Phytoestrogens; 0/Plant Extracts; 0/Prebiotics; 529-59-9/genistin |
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