| The Combination of Framingham Risk Score and Carotid Intima-Media Thickness Improves the Prediction of Cardiovascular Events in Patients With Type 2 Diabetes. | |
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MedLine Citation:
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PMID: 22028278 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVEThe aim of this study was to investigate whether carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) add value to the Framingham risk score (FRS) in predicting the development of cardiovascular diseases (CVDs) in type 2 diabetic patients with a negative history of CVD.RESEARCH DESIGN AND METHODSType 2 diabetic patients (n = 783) were retrospectively recruited and followed for CVD.RESULTSDuring a 5.4-year follow-up period, 85 incidences of CVD were recorded (10.9%). After adjustment for conventional arterial risk factors, multivariate analysis with the Cox proportional hazards model identified IMT, but not baPWV, as a significant determinant of CVD. In addition, the combination of FRS with IMT, but not with baPWV, improved the prediction of CVD.CONCLUSIONSCarotid IMT is a significant predictor of CVD in asymptomatic type 2 diabetic patients, and the combination of FRS and IMT improves the prediction of CVD in these patients. |
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Authors:
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Michiko Yoshida; Tomoya Mita; Risako Yamamoto; Tomoaki Shimizu; Fuki Ikeda; Chie Ohmura; Akio Kanazawa; Takahisa Hirose; Ryuzo Kawamori; Hirotaka Watada |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-25 |
Journal Detail:
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Title: Diabetes care Volume: - ISSN: 1935-5548 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, Metabolism, and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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