Document Detail

Combination of Antihypertensive Therapy in The Elderly, Multicenter Investigation (CAMUI) Trial.
MedLine Citation:
PMID:  22878803     Owner:  NLM     Status:  Publisher    
Angiotensin receptor blockers (ARBs) with calcium channel blockers (CCBs) or diuretics are a widely used combination therapy for hypertensive patients. The present study aimed to determine which combination was better for elderly hypertension patients aged ≧ 65 years.We designed a multicentre, randomized, open-label, parallel comparison study. Hypertensive outpatients aged ≧ 65 years who did not achieve the target blood pressure (BP < 140/90 mmHg) with usual dosages of ARBs were randomly assigned to switch treatment to losartan 50 mg/hydrochlorothiazide 12.5 mg or amlodipine 5 mg in addition to ARBs. The primary endpoint was a change in the systolic blood pressure (SBP) and diastolic blood pressure (DBP) after the 3-month treatment period, while secondary endpoints were changes in the BP, albuminuria, laboratory values, and cognitive function with the mini-mental state examination (MMSE) at baseline and after one year. The results from the CAMUI trial should provide new evidence for selecting optimal combination therapies for elderly hypertensive patients.
Nobuyuki Sato; Yasuaki Saijo; Naoyuki Hasebe;
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Publication Detail:
Journal Detail:
Title:  International heart journal     Volume:  53     ISSN:  1349-3299     ISO Abbreviation:  Int Heart J     Publication Date:  2012  
Date Detail:
Created Date:  2012-8-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  244-248     Citation Subset:  -    
Department of Cardiolog, Asahikawa Medical University.
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