| Combination of Antihypertensive Therapy in The Elderly, Multicenter Investigation (CAMUI) Trial. | |
| | |
MedLine Citation:
|
PMID: 22878803 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Angiotensin receptor blockers (ARBs) with calcium channel blockers (CCBs) or diuretics are a widely used combination therapy for hypertensive patients. The present study aimed to determine which combination was better for elderly hypertension patients aged ≧ 65 years.We designed a multicentre, randomized, open-label, parallel comparison study. Hypertensive outpatients aged ≧ 65 years who did not achieve the target blood pressure (BP < 140/90 mmHg) with usual dosages of ARBs were randomly assigned to switch treatment to losartan 50 mg/hydrochlorothiazide 12.5 mg or amlodipine 5 mg in addition to ARBs. The primary endpoint was a change in the systolic blood pressure (SBP) and diastolic blood pressure (DBP) after the 3-month treatment period, while secondary endpoints were changes in the BP, albuminuria, laboratory values, and cognitive function with the mini-mental state examination (MMSE) at baseline and after one year. The results from the CAMUI trial should provide new evidence for selecting optimal combination therapies for elderly hypertensive patients. |
| | |
Authors:
|
Nobuyuki Sato; Yasuaki Saijo; Naoyuki Hasebe; |
Related Documents
:
|
17224953 - Comparison of proview phosphene tonometry with goldmann applanation tonometry. 2028773 - Correlation of some ocular and hematologic factors and intraocular pressure in an aged ... 15679303 - Noninvasive intracranial compliance and pressure based on dynamic magnetic resonance im... |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: International heart journal Volume: 53 ISSN: 1349-3299 ISO Abbreviation: Int Heart J Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-8-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101244240 Medline TA: Int Heart J Country: - |
Other Details:
|
Languages: ENG Pagination: 244-248 Citation Subset: - |
Affiliation:
|
Department of Cardiolog, Asahikawa Medical University. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of anemia correction by erythropoiesis-stimulating agents on cardiovascular function in non-...
Next Document: Intrathoracic impedance changes reflect reverse left ventricular remodeling in response to cardiac r...