| Combination of Allergic Factors Can Worsen Diarrheic Irritable Bowel Syndrome: Role of Barrier Defects and Mast Cells. | |
| | |
MedLine Citation:
|
PMID: 21931380 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES:Recent evidence suggests a role for increased colonic permeability and mucosal mast cell (MC) mediators on symptoms related to the irritable bowel syndrome (IBS). Whether allergic factors (AFs) are involved in the pathophysiology of IBS is unclear. We addressed the question of the possible influence of an allergic background on IBS symptoms.METHODS:We assessed paracellular permeability, mucosal MCs counts, and spontaneous release of tryptase of colonic biopsy specimens in 34 IBS patients and 15 healthy subjects. The severity of IBS was assessed through self-reported questionnaires. All individuals were tested for the presence of AF, including self-perception of adverse reaction to food, personal and familial history of atopic disease, elevated total or specific immunoglobulin E against food/inhalant antigens, blood eosinophilia, and skin tests.RESULTS:IBS patients had significant enhanced colonic permeability, higher number of MCs, and spontaneous release of tryptase than healthy subjects. The severity of IBS was significantly correlated with colonic permeability (r=0.48, P=0.004), MCs counts (r=0.36, P=0.03), and tryptase (r=0.48, P=0.01). In 13 IBS patients (38.2%) having at least three AFs, symptoms scores, colonic permeability, MCs counts, and tryptase release by colonic biopsies were significantly higher than in those with less than three AFs. IBS patients with at least three AFs were more prone to diarrhea or alternating symptoms. None AF was found to be predictive of IBS severity.CONCLUSIONS:In IBS patients, the presence of an allergic background correlates with a more severe disease and diarrhea predominance, possibly by enhancing mucosal MC activation and paracellular permeability.Am J Gastroenterol advance online publication, 20 September 2011; doi:10.1038/ajg.2011.315. |
| | |
Authors:
|
M Vivinus-Nébot; R Dainese; R Anty; M C Saint-Paul; J L Nano; N Gonthier; S Marjoux; G Frin-Mathy; G Bernard; X Hébuterne; A Tran; V Theodorou; T Piche |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-9-20 |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: - ISSN: 1572-0241 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-9-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1] Department of Immunology, Pole of Biology, Université de Nice Sophia-Antipolis, CHU de Nice, Nice, France [2] INSERM U576, Nice, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Direct Measurement of Gastroesophageal Reflux Episodes in Patients With Squamous Cell Carcinoma by 2...
Next Document: Heat-generating property of a local plasmon resonator under illumination.