Document Detail


Combating hepatitis C virus by targeting microRNA-122 using locked nucleic acids.
MedLine Citation:
PMID:  22856605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MicroRNAs have been predicted to regulate the stability and translation of many target mRNAs that are involved in modulating disease outcome. Thus, valuable strategies to enhance or to diminish the function of microRNAs are needed to manipulate microRNA-mediated target gene expression. Recently, it has become apparent that one class of antisense oligonucleotides, locked nucleic acids, can be used to sequester microRNAs in the liver of a variety of animals including humans, opening the possibility of applying locked nucleic acid-mediated gene therapy. This review summarizes the success of sequestration of liver-specific microRNA miR-122 by antisense locked nucleic acids and their use in combating hepatitis C virus in clinical trials.
Authors:
Erica S Machlin; Peter Sarnow; Selena M Sagan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current gene therapy     Volume:  12     ISSN:  1875-5631     ISO Abbreviation:  Curr Gene Ther     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-03     Completed Date:  2012-12-18     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101125446     Medline TA:  Curr Gene Ther     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Genetic Therapy
Hepacivirus* / genetics,  pathogenicity
Hepatitis C / genetics,  therapy*
Humans
Liver / metabolism,  virology
MicroRNAs* / antagonists & inhibitors,  genetics,  metabolism
Molecular Targeted Therapy
Nucleic Acids / chemistry,  therapeutic use
Oligonucleotides, Antisense / genetics,  metabolism,  therapeutic use*
RNA, Viral / antagonists & inhibitors,  genetics
Grant Support
ID/Acronym/Agency:
5T32 AI007328/AI/NIAID NIH HHS; AI069000/AI/NIAID NIH HHS; AI47365/AI/NIAID NIH HHS; T32 AI007328/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/MIRN122 microRNA, human; 0/MicroRNAs; 0/Nucleic Acids; 0/Oligonucleotides, Antisense; 0/RNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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