| Coma blisters, peripheral neuropathy, and amitriptyline overdose: a brief report. | |
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MedLine Citation:
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PMID: 12447625 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Coma blisters are most commonly associated with barbiturate and benzodiazepine overdose; however, they have also been described in association with many other substances, including amitriptyline. OBJECTIVE: To review the literature on the clinical manifestations of coma blisters in the setting of amitriptyline overdose. METHODS: Case report and literature review. RESULTS: Coma blisters in association with amitriptyline overdose have rarely been documented in the literature. Of the few reported cases, peripheral neuropathy has been present two (including our case report) out of four times. CONCLUSION: Amitriptyline is known to impair endothelial cell tight junction integrity. Thus, individuals with amitriptyline overdose may be predisposed to microvascular damage during the compression imposed from a comatose state. This may help to explain the tendency for patients to present with the interesting triad of coma, blisters, and neuropathy. |
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Authors:
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Sheilagh Maguiness; Lyn Guenther; David Shum |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2002-07-16 |
Journal Detail:
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Title: Journal of cutaneous medicine and surgery Volume: 6 ISSN: 1203-4754 ISO Abbreviation: J Cutan Med Surg Publication Date: 2002 Sep-Oct |
Date Detail:
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Created Date: 2002-11-26 Completed Date: 2003-06-02 Revised Date: 2007-07-04 |
Medline Journal Info:
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Nlm Unique ID: 9614685 Medline TA: J Cutan Med Surg Country: United States |
Other Details:
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Languages: eng Pagination: 438-41 Citation Subset: IM |
Affiliation:
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University of Western Ontario, London, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amitriptyline / poisoning* Antidepressive Agents, Tricyclic / poisoning* Blister / chemically induced*, pathology Coma / chemically induced*, pathology Female Humans Overdose Peripheral Nervous System Diseases / chemically induced* |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Tricyclic; 50-48-6/Amitriptyline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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