Document Detail

Coma blisters in 2 children on anticonvulsant medication.
MedLine Citation:
PMID:  19359256     Owner:  NLM     Status:  MEDLINE    
Blister formation and eccrine sweat gland necrosis have been recognized to occur in states of impaired consciousness and were first reported following barbiturate intoxication. Their etiology is complex and cannot simply be explained by pressure effects. Now that barbiturates are less frequently used, clinicians are likely to be less aware of the phenomenon of coma blister formation; however, newer drugs have also been associated with the occurrence of coma blisters. We describe 2 new associations of coma blisters and anticonvulsants in children. In the first child, blisters recurred on multiple occasions along with obtundation and edema. Our aims are to alert clinicians to the occurrence of coma blisters in children sedated on anticonvulsant medications and to report the new finding of recurrent coma blisters.
Anna Basu; Sara Brown; Nigel Kirkham; Venkateswaran Ramesh; Suzy Leech; Anita Devlin
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-04-08
Journal Detail:
Title:  Journal of child neurology     Volume:  24     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1021-5     Citation Subset:  IM    
Department of Paediatric Neurology, Newcastle General Hospital, Newcastle Upon Tyne, United Kingdom.
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MeSH Terms
Anticonvulsants / adverse effects*,  therapeutic use
Blister / chemically induced,  etiology*
Edema / chemically induced
Epilepsy / drug therapy
Treatment Outcome
Reg. No./Substance:

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