| Columnar-lined oesophagus without intestinal metaplasia: results from a cohort with a mean follow-up of 7 years. | |
| | |
MedLine Citation:
|
PMID: 22670705 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: The definition of Barrett's oesophagus lacks consensus, particularly the requirement of intestinal metaplasia for diagnosis. Scarce information exists on the prevalence and natural history of columnar-lined oesophagus without intestinal metaplasia. AIM: To evaluate the demographics and natural history of columnar-lined oesophagus without intestinal metaplasia ≥2 cm in length. METHODS: Patients with columnar-lined oesophagus ≥2 cm in length and no intestinal metaplasia in biopsy specimens from two consecutive endoscopies with at least a 1-year interval were prospectively followed. A cohort of Barrett's oesophagus patients was used as a control. RESULTS: Columnar-lined oesophagus without intestinal metaplasia (n = 15) had a similar gender distribution, reflux symptoms prevalence and length as those of Barrett's oesophagus (n = 205). Patients were significantly younger (28.6 vs. 60 years, P < 0.0001) and accounted for 48% of patients aged <40 years in the two cohorts, but only 1% of those aged >40 years (P < 0.001). Patient distribution in both cohorts in 5 age brackets (0-19, 20-29, 30-39, 40-49, and >50 years) was significantly different, except for patients aged 40-49 years. Intestinal metaplasia was documented in 60% of the cohort after a mean follow-up of 7.1 years. CONCLUSIONS: Columnar-lined oesophagus without intestinal metaplasia ≥2 cm is infrequent in the setting of a systematic biopsy protocol, is associated with a younger age in comparison with Barrett's oesophagus, and appears to be an intermediate step between squamous and intestinal lining of the oesophagus. |
| | |
Authors:
|
A Dias Pereira; P Chaves |
Related Documents
:
|
22826625 - Gender preference and implications for screening colonoscopy: impact of endoscopy nurses. 1094565 - The use of pyrithioxine in a group of visually handicapped children. a preliminary repo... 2622645 - Binocular vision, age and symptoms. 2376405 - Performance of young and older drivers on a static acuity test under photopic and mesop... 9685455 - Adult height in children with growth hormone deficiency who are treated with biosynthet... 22387595 - Self and body esteem perception in multiple sclerosis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-6-3 |
Journal Detail:
|
Title: Alimentary pharmacology & therapeutics Volume: - ISSN: 1365-2036 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-6-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8707234 Medline TA: Aliment Pharmacol Ther Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 Blackwell Publishing Ltd. |
Affiliation:
|
Department of Gastroenterology, Instituto Português de Oncologia de Lisboa de Francisco Gentil, EPE, Lisbon, Portugal; Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Negative HCV-RNA 2 weeks after initiation of treatment predicts sustained virological response to pe...
Next Document: Immunoglobulin?G dimers and immune complexes are dispensable for the therapeutic efficacy of intrave...