Document Detail


Columnar processing in primate pFC: evidence for executive control microcircuits.
MedLine Citation:
PMID:  23016850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A common denominator for many cognitive disorders of human brain is the disruption of neural activity within pFC, whose structural basis is primarily interlaminar (columnar) microcircuits or "minicolumns." The importance of this brain region for executive decision-making has been well documented; however, because of technological constraints, the minicolumnar basis is not well understood. Here, via implementation of a unique conformal multielectrode recording array, the role of interlaminar pFC minicolumns in the executive control of task-related target selection is demonstrated in nonhuman primates performing a visuomotor DMS task. The results reveal target-specific, interlaminar correlated firing during the decision phase of the trial between multielectrode recording array-isolated minicolumnar pairs of neurons located in parallel in layers 2/3 and layer 5 of pFC. The functional significance of individual pFC minicolumns (separated by 40 μm) was shown by reduced correlated firing between cell pairs within single minicolumns on error trials with inappropriate target selection. To further demonstrate dependence on performance, a task-disrupting drug (cocaine) was administered in the middle of the session, which also reduced interlaminar firing in minicolumns that fired appropriately in the early (nondrug) portion of the session. The results provide a direct demonstration of task-specific, real-time columnar processing in pFC indicating the role of this type of microcircuit in executive control of decision-making in primate brain.
Authors:
Ioan Opris; Robert E Hampson; Greg A Gerhardt; Theodore W Berger; Sam A Deadwyler
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-09-27
Journal Detail:
Title:  Journal of cognitive neuroscience     Volume:  24     ISSN:  1530-8898     ISO Abbreviation:  J Cogn Neurosci     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-10-31     Completed Date:  2013-04-11     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  8910747     Medline TA:  J Cogn Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2334-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cocaine / pharmacology
Cognition / drug effects
Data Interpretation, Statistical
Dopamine / physiology
Dopamine Uptake Inhibitors / pharmacology
Electrodes, Implanted
Electrophysiological Phenomena / physiology
Executive Function / drug effects,  physiology*
Macaca mulatta
Nerve Net / drug effects,  physiology*
Prefrontal Cortex / drug effects,  physiology*
Psychomotor Performance / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
DA023573/DA/NIDA NIH HHS; DA026487/DA/NIDA NIH HHS; DA06634/DA/NIDA NIH HHS; P50 DA006634/DA/NIDA NIH HHS; R01 DA023573/DA/NIDA NIH HHS; R01 DA026487/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Dopamine Uptake Inhibitors; I5Y540LHVR/Cocaine; VTD58H1Z2X/Dopamine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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