Document Detail

Column liquid chromatographic analysis of quinine in human plasma, saliva and urine.
MedLine Citation:
PMID:  8376486     Owner:  NLM     Status:  MEDLINE    
A new simple, selective and reproducible high-performance liquid chromatographic method for the determination of quinine in plasma, saliva and urine is described. The ion-pair method was carried out on a reversed-phase C18 column, using perchlorate ion as the counter ion and ultraviolet detection at 254 nm. Quinine was well resolved from its major metabolite, 3-hydroxyquinine, and the internal standard, primaquine. The limit of detection was 10 ng/ml and the recovery was greater than 90% from the three biological fluids.
C P Babalola; O O Bolaji; P A Dixon; F A Ogunbona
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatography     Volume:  616     ISSN:  -     ISO Abbreviation:  J. Chromatogr.     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-10-21     Completed Date:  1993-10-21     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0427043     Medline TA:  J Chromatogr     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  151-4     Citation Subset:  IM    
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MeSH Terms
Chromatography, High Pressure Liquid
Indicators and Reagents
Primaquine / analysis,  blood,  urine
Quinidine / analogs & derivatives,  analysis,  blood,  urine
Quinine / analysis*,  blood,  urine
Saliva / chemistry*
Spectrophotometry, Ultraviolet
Reg. No./Substance:
0/Indicators and Reagents; 53467-23-5/3-hydroxyquinidine; A7V27PHC7A/Quinine; ITX08688JL/Quinidine; MVR3634GX1/Primaquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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