Document Detail

Colour-Doppler ultrasonography of carotid vessels in patients treated with antiretroviral therapy: a comparative study.
MedLine Citation:
PMID:  15096805     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the correlation between antiretroviral therapy (ART) and lesions of the carotid vessels using an ultrasound colour-Doppler technique. DESIGN: A total of 293 HIV-1 infected patients underwent epiaortic vessel ultrasonography: 105 on treatment with protease inhibitors (PI) (group I), 125 PI-naive patients treated with a non-nucleoside reverse transcriptase inhibitor-including regimen (group II), and 63 patients treated with two nucleoside reverse transcriptase inhibitors or naive to ART (group III). METHODS: Intima characteristics, pulsation and resistance indexes, and minimal, peak and mean speed were evaluated using a colour power doppler. Atherosclerotic plaques were described. Independent risk factors and values for glycaemia, cholesterolaemia and triglyceridaemia were considered. Statistical analysis included the Wilcoxon tests, the chi test, the Cochran Armitage trend test and the Mantel-Haenszel test and, when necessary, logistic regression analysis. RESULTS: Of the 150 group I patients, 55 (52.4%) presented acquired lesions of the vascular wall at ultrasonography, whereas similar lesions were found in 19 out of 125 (15.2%) patients in group II and in nine of 63 (14.3%) in group III. ART, age, smoking and CD4 T-cell count were the main predictive risk factors for vascular lesions. However, the highest significance was with the use of PI. CONCLUSIONS: These data confirm the higher prevalence of premature carotid lesions in the PI-treated patients. A periodic ultrasonographic study of the vascular wall should be included in the follow-up of HIV infected patients.
Paolo Maggi; Antonio Lillo; Francesco Perilli; Renato Maserati; Antonio Chirianni;
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  AIDS (London, England)     Volume:  18     ISSN:  0269-9370     ISO Abbreviation:  AIDS     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-20     Completed Date:  2004-08-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  1023-8     Citation Subset:  IM; X    
Infectious Disease Clinic, Policlinico, University of Bari, Italy.
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MeSH Terms
Anti-HIV Agents / adverse effects*
Carotid Artery Diseases / chemically induced*,  ultrasonography*
HIV Infections / drug therapy
HIV Protease Inhibitors / adverse effects
Middle Aged
Reverse Transcriptase Inhibitors / adverse effects
Risk Factors
Ultrasonography, Doppler, Color
Reg. No./Substance:
0/Anti-HIV Agents; 0/HIV Protease Inhibitors; 0/Reverse Transcriptase Inhibitors

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