| Colostrum protein concentrate enhances intestinal adaptation after massive small bowel resection in juvenile pigs. | |
| | |
MedLine Citation:
|
PMID: 15572887 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Short bowel syndrome (SBS) usually results from the surgical removal of a large segment of small intestine. Patient outcome depends on the extent of intestinal resection and adaptation of the remaining intestine. We evaluated the impact of colostrum protein concentrate (CPC) on intestinal adaptation after massive small bowel resection in a porcine model of infant SBS. METHODS: Four-week-old piglets underwent an approximate 75% small bowel resection (R, n = 23) or a control transection operation (C, n = 14). Postoperatively, animals from both groups received either pig chow (R = 6, C = 5), polymeric infant formula (R = 6, C = 3) or polymeric infant formula supplemented with CPC (R = 11, C = 6) for 8 weeks until sacrifice. Clinical outcome measures included weight gain and stool consistency. Morphologic measures were intestinal villus height and crypt depth. Functional outcome measure was mucosal disaccharidase activity. RESULTS: Resected animals fed polymeric infant formula alone had reduced weight gain compared with controls fed the same diet (P < 0.005). Despite massive small bowel resection, animals fed pig chow or polymeric infant formula supplemented with CPC grew at an equivalent rate to controls fed polymeric infant formula alone. Resected animals supplemented with CPC had increased villus length and crypt depth in the jejunum (P < 0.001) and ileum (P < 0.001) compared with resected animals fed either pig chow or polymeric infant formula alone. CONCLUSION: In an animal model of SBS, CPC supplementation of polymeric infant formula resulted in normal weight gain and features of enhanced morphologic adaptation. |
| | |
Authors:
|
Eva S Nagy; Monique C J Paris; Russell G Taylor; Peter J Fuller; Magdy Sourial; Fran Justice; Julie E Bines |
Related Documents
:
|
11288507 - Clinical and economic outcomes of infants receiving breast milk in the nicu. 17130747 - Effects of bovine alpha-lactalbumin and casein glycomacropeptide-enriched infant formul... 6737187 - Effects of zinc and copper content of formulas on growth and on the concentration of zi... 9085017 - Lipid supply for infants with special needs. 3789997 - Sudden infant death syndrome in tasmania, 1975-81. 9431297 - The epidemiology of necrotizing enterocolitis infant mortality in the united states. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of pediatric gastroenterology and nutrition Volume: 39 ISSN: 0277-2116 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2004 Nov |
Date Detail:
|
Created Date: 2004-12-01 Completed Date: 2005-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 487-92 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Parkville, Victoria, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological
/
drug effects* Animals Colostrum* / chemistry Disaccharidases / metabolism Disease Models, Animal Feces Female Humans Infant Infant Formula Infant, Newborn Intestinal Mucosa / enzymology, pathology* Intestine, Small / pathology, surgery Postoperative Period Proteins / therapeutic use* Random Allocation Short Bowel Syndrome / drug therapy* Swine Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Proteins; EC 3.2.1.-/Disaccharidases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thirty years of the ESPGAN/ESPGHAN Committee on Nutrition.
Next Document: Meat consumption is positively associated with psychomotor outcome in children up to 24 months of ag...