Document Detail


Colors with functions: elucidating the biochemical and molecular basis of carotenoid metabolism.
MedLine Citation:
PMID:  20415581     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Carotenoids affect a rich variety of physiological functions in nature and are beneficial for human health, serving as antioxidants in lipophilic environments and blue light filters in the macula of human retina. These dietary compounds also serve as precursors of a unique set of apo-carotenoid cleavage products, including retinoids. Although knowledge about retinoid biology has tremendously increased, the metabolism of retinoids' parent precursors remains poorly understood. Recently, molecular players in carotenoid metabolism have been identified and biochemically characterized. Moreover, mutations in their corresponding genes impair carotenoid metabolism and induce various pathologies in animal models. Polymorphisms in these genes alter carotenoid and retinoid homeostasis in humans as well. This review summarizes our current knowledge about the molecular/biochemical basis of carotenoid metabolism and particularly the physiological role of carotenoids in retinoid-dependent physiological processes.
Authors:
Johannes von Lintig
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of nutrition     Volume:  30     ISSN:  1545-4312     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-56     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4965, USA. jxv99@case.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / chemistry,  metabolism,  physiology
Carotenoids / chemistry,  metabolism*,  physiology
Drosophila
Humans
Models, Animal
Polymorphism, Genetic
Retina / chemistry,  metabolism
Grant Support
ID/Acronym/Agency:
EY019641/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 36-88-4/Carotenoids

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