Document Detail


Colorimetric determination of macrolide antibiotics using ferric ion.
MedLine Citation:
PMID:  18966372     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Macrolide antibiotics such as erythromycin, oleandomycin, spiromycin, and tylosin are found to react with Fe(3+) in the presence of an acetic acid-sulfuric acid mixture to form a colored product having a useful absorption band at 592 nm. Troleandomycin forms only a weakly colored product upon reaction. The molar absorptivity is about 2900 1 mol(-1) cm(-1) for erythromycin and the detection limit is 5 mug ml(-1). This colorimetric method permits the analysis of fermentation broths containing either erythromycin or tylosin without a separation step.
Authors:
P A Gallagher; N D Danielson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Talanta     Volume:  42     ISSN:  0039-9140     ISO Abbreviation:  Talanta     Publication Date:  1995 Oct 
Date Detail:
Created Date:  2008-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  England    
Other Details:
Languages:  eng     Pagination:  1425-32     Citation Subset:  -    
Affiliation:
Department of Chemistry, Miami University, Oxford, OH 45056, USA.
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