| Color Doppler sonographic detection of tumor flow in superficial melanoma metastases: histologic correlation. | |
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MedLine Citation:
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PMID: 9527572 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Color Doppler sonographic detection of tumor flow within superficial melanoma metastases was investigated to determine if tumor size, vessel size, or vessel number influences signal detection. Color Doppler imaging of 32 pathologically proved melanoma metastases was performed at 6 MHz with color Doppler imaging parameters optimized for each lesion scanned. All lesions were measured in three dimensions and the presence or absence of internal flow was documented. Seven surgically excised metastases underwent immunohistochemical staining for endothelial markers. Internal flow was detected in 21 of 32 masses and was completely absent in 11. In comparison to all masses without flow, the masses with flow had significantly greater anteroposterior dimensions (P < 0.00036) and volumes (P < 0.01). Histologically, mean vessel diameter in masses with flow was significantly greater (P < 0.05) than in those without flow, but mean vessel number was not significantly different. In conclusion, detectability of tumor blood flow in superficial melanoma metastasis may be related more to tumor size and vessel size than vessel number. Failure to detect color signal within a superficial melanoma mass does not indicate a lack of internal vascularity. |
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Authors:
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A A Alexander; L N Nazarian; D M Capuzzi; N M Rawool; A B Kurtz; M J Mastrangelo |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine Volume: 17 ISSN: 0278-4297 ISO Abbreviation: J Ultrasound Med Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-03-27 Completed Date: 1998-03-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8211547 Medline TA: J Ultrasound Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 123-6 Citation Subset: IM |
Affiliation:
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Jefferson Ultrasound Research and Education Institute, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antigens, CD34 / diagnostic use Blood Vessels / pathology, ultrasonography Coloring Agents / diagnostic use Endothelium, Vascular / pathology Humans Immunohistochemistry Melanoma / blood supply*, pathology, secondary, ultrasonography Middle Aged Regional Blood Flow Skin Neoplasms / blood supply*, pathology, secondary, ultrasonography Ultrasonography, Doppler, Color* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD34; 0/Coloring Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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