| Color Doppler imaging and plasma levels of endothelin-1 in low-tension glaucoma. | |
| | |
MedLine Citation:
|
PMID: 9589707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Endothelin-1 (ET-1) is a potent vasoconstrictor peptide produced by vascular endothelin cells There are reports in the literature that ET-1 plasma levels are raised in low tension glaucoma (LTG). ET-1 plasma concentration and Color Doppler Imaging (CDI) evaluation in ophthalmic and posterior ciliary arteries were measured in 15 LTG patients and in 15 healthy subjects. The blood flow index recorded for the ophthalmic artery in normal subjects was a PSV of 36.646 +/- 6.611 cm/sec with RI of 0.717 +/- 0.019 while in the LTG patients it was 32.961 +/- 3.045 cm/sec (p < 0.003) with RI of 0.789 +/- 0.018 (p < 0.001). For the posterior ciliary arteries in the same two groups, we obtained a PSV of 13.878 +/- 4.149 cm/sec vs 8.720 +/- 1.645 cm/sec (p < 0.001) and an RI of 0.679 +/- 0.039 vs 0.722 +/- 0.024 (p < 0.001). The plasma ET-1 level in normal subjects was 1.720 +/- 0.174 pg while in LTG patients it was 2.947 +/- 0.217 pg (p < 0.001). On the basis of our experience, we think that GON and the visual field damage found in LTG can be attributed to an alteration in the endothelial self-regulating sections and consequent vascular insufficiency, particularly pronounced in the posterior ciliary arteries which, since it is these that provide the blood supply to the optic nerve head, leads to irreversible functional damage. |
| | |
Authors:
|
M Cellini; G L Possati; V Profazio; M Sbrocca; N Caramazza; R Caramazza |
Related Documents
:
|
20203067 - High-resolution spatial measurements of ventilation-perfusion heterogeneity in rats. 8591307 - Estimation of blood flow in the upper gastrointestinal tract by analysis of endoscopic ... 2805867 - Visualization of coronary blood flow by color doppler imaging with a transesophageal ap... 15927537 - A novel method for the assessment of the accuracy of computing laminar flow stroke volu... 169527 - Investigation of some materials as dry binders for direct compression in tablet manufac... 11716327 - Spontaneous echo contrast in descending aorta correlates with low blood-flow velocity i... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Acta ophthalmologica Scandinavica. Supplement Volume: - ISSN: 1395-3931 ISO Abbreviation: Acta Ophthalmol Scand Suppl Publication Date: 1997 |
Date Detail:
|
Created Date: 1998-07-09 Completed Date: 1998-07-09 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9516974 Medline TA: Acta Ophthalmol Scand Suppl Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 11-3 Citation Subset: IM |
Affiliation:
|
Eye Clinic, University of Bologna. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Biological Markers / blood Blood Flow Velocity Ciliary Arteries / physiopathology, ultrasonography* Endothelin-1 / blood* Female Glaucoma, Open-Angle / blood, physiopathology, ultrasonography* Humans Intraocular Pressure Male Middle Aged Ophthalmic Artery / physiopathology, ultrasonography* Optic Disk / blood supply Ultrasonography, Doppler, Color* Visual Fields |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Endothelin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Potent inhibitory effect of troglitazone on carotid arterial wall thickness in type 2 diabetes.
Next Document: Estimating glaucomatous anatomical damage by computerized automated perimetry.