Document Detail

Color Doppler flow mapping of the patent ductus arteriosus in very low birthweight neonates: echocardiographic and clinical findings.
MedLine Citation:
PMID:  7997425     Owner:  NLM     Status:  MEDLINE    
Forty-eight preterm infants (mean birthweight 1.0 +/- 0.3 kg; mean gestational age 28 +/- 3 weeks) underwent serial echocardiograms and physical examinations in order to determine the correlation between color Doppler flow mapping (CDFM) results and physical findings of a patent ductus arteriosus (PDA), the predictive value of early CDFM as an indicator of subsequent requirement for treatment of a PDA, and to determine the direction and duration of ductal shunting and the rate of ductal closure and opening. CDFM analysis and cardiac physical examination of left-to-right ductal shunting were usually concordant in infants with a large PDA shunt, the most reliable physical finding being increased precordial activity. CDFM studies on day 2 or 3 of postnatal life had prognostic value with regard to subsequent need for closing the PDA. Additional findings included the absence of right-to-left PDA shunting in infants < 1 kg and < 28 weeks gestation and the absence of ductal reopening in infants in whom it had closed spontaneously. After complete PDA closure using indomethacin, subsequent ductal reopening is uncommon, except in infants < 25 weeks gestation and < 700 g bodyweight.
D A Roberson; N H Silverman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric cardiology     Volume:  15     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1995-01-13     Completed Date:  1995-01-13     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  219-24     Citation Subset:  IM    
Department of Pediatrics, University of California, San Francisco.
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MeSH Terms
Ductus Arteriosus, Patent / diagnosis,  therapy,  ultrasonography*
Echocardiography, Doppler, Color*
Indomethacin / therapeutic use
Infant, Low Birth Weight / physiology*
Infant, Newborn
Infant, Premature
Physical Examination
Prospective Studies
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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