Document Detail

Color Doppler evaluation of the ocular arterial flow changes in chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  16051458     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the hemodynamic changes in the extraocular orbital vessels of the patients with chronic obstructive pulmonary disease (COPD), using color Doppler ultrasonography (CDU) technique, and to compare the results with those of healthy control subjects. METHODS: Forty-five patients with COPD and 17 healthy control subjects were included in this study. Patients with COPD were classified according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Fifteen patients of stage I COPD (mild airflow limitation), stage II COPD (worsening airflow limitation) or stage III COPD (severe airflow limitation) were enrolled into Group I, II and III, respectively. End tidal carbon dioxide (EtCO(2)), peripheral oxygen saturation (SpO(2)), pulse rate (PR) and respiratory rate (RR) were measured by using capnograph/pulse oximeter in all patients. Measurements were performed in only one randomly chosen eye of each participant. The peak systolic velocity (PSV), end-diastolic velocity (EDV), and resistance index (RI) were measured in the ophthalmic artery (OA), central retinal artery (CRA), lateral short posterior ciliary artery (LPCA) and medial short posterior ciliary artery (MPCA), using CDU technique. RESULTS: The PSV measurements of the OA were significantly higher in Groups II and III compared to control group (p < 0.01, p < 0.001, respectively). The RI values from OA and CRA were significantly higher in Group II and III than the control group (p < 0.05). The RI values of LPCA and MPCA were also significantly higher in Group II than the control subjects (p < 0.05). When RI values were compared, mean values of LPCA and MPCA were significantly lower in Group III than in Group II (p < 0.05). There were no significant differences between Group I and control patients about PSVs, EDVs and RI values of all arteries Statistically significant correlations were found for the EtCO(2) with PSV (r = 0.53, p < 0.01) and EDV (r = 0.51, p < 0.01) of the OA. Statistically significant correlations were also found for the SpO2 with RI (r = -0.34, p < 0.05) in the OA. CONCLUSION: We concluded that COPD is associated with impaired retrobulbar hemodynamics, especially in the ophthalmic artery. Moreover, central retinal and posterior ciliary arteries with increased resistance are also found to be affected when compared with healthy control eyes.
Tulay Ozer; Remzi Altin; Suat Hayri Ugurbas; Yetkin Ozer; Kamran Mahmutyazicioglu; Levent Kart
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Publication Detail:
Type:  Journal Article     Date:  2005-07-26
Journal Detail:
Title:  European journal of radiology     Volume:  57     ISSN:  0720-048X     ISO Abbreviation:  Eur J Radiol     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
Department of Radiology, Karaelmas University, School of Medicine, Tip Fakültesi, Radyoloji AD, Kozlu, Zonguldak, Turkey.
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MeSH Terms
Analysis of Variance
Blood Flow Velocity
Case-Control Studies
Ciliary Arteries / physiopathology*,  ultrasonography*
Middle Aged
Ophthalmic Artery / physiopathology*,  ultrasonography*
Prospective Studies
Pulmonary Disease, Chronic Obstructive / physiopathology*
Regional Blood Flow
Respiratory Function Tests
Retinal Artery / physiopathology*,  ultrasonography*
Ultrasonography, Doppler, Color

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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