Document Detail

Colony stimulating factor occurs in both inflammatory and noninflammatory synovial fluids.
MedLine Citation:
PMID:  2203135     Owner:  NLM     Status:  MEDLINE    
Synovial fluids (SF) from patients with osteoarthritis (OA) and rheumatoid arthritis (RA) and various other arthritides were examined for the presence of colony stimulating factors (CSF). CSF was found in 7 of 13 (54%) SF from OA patients and in 8 of 12 (67%) SF from RA patients. It was also found in SF from patients with other arthropathies including 5 of 5 samples from patients with septic arthritis. Inhibition studies employing monospecific antisera indicated that in both RA and OA, CSF was of the macrophage type (M-CSF). While CSF was found in both inflammatory and noninflammatory effusions, significantly greater numbers of colonies were stimulated by RA SF than by OA SF and in general greater numbers of colonies correlated with higher SF leukocyte counts. Our data suggest that CSF as well as other cytokines may be involved in the perpetuation of joint destruction that occurs in various rheumatological conditions.
J B Smith; M H Bocchieri; J B Smith; L Sherbin-Allen; J L Abruzzo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Rheumatology international     Volume:  10     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  1990  
Date Detail:
Created Date:  1990-10-04     Completed Date:  1990-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  131-4     Citation Subset:  IM    
Department of Medicine, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
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MeSH Terms
Arthritis, Rheumatoid / immunology,  metabolism
Colony-Stimulating Factors / analysis*,  immunology,  metabolism
Immune Sera / immunology
Immunologic Techniques
Inflammation / immunology*
Osteoarthritis / immunology,  metabolism
Synovial Fluid / analysis*,  immunology,  metabolism
Reg. No./Substance:
0/Colony-Stimulating Factors; 0/Immune Sera

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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