| Colony stimulating factor-1 expression is developmentally regulated in the mouse. | |
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MedLine Citation:
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PMID: 8691066 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Colony stimulating factor-1 (CSF-1) regulates the survival, proliferation, and differentiation of mononuclear phagocytes. To determine whether CSF-1 plays a role in the perinatal development of these cells, CSF-1 protein and mRNA expression in tissues and serum from fetal/neonatal mice and their mothers was analyzed. As fetal/neonatal age increased, CSF-1 concentrations rose in liver, kidney, and lung, declined in brain and serum, and did not change in intestine and heart. Concurrently, fetal/neonatal CSF-1 concentrations were higher in liver, kidney, and serum and lower in lung, brain, intestine, and heart than maternal tissue/serum concentrations, which showed no correlations with gestational or postpartum stage. CSF-1 mRNA was detected in all tissues examined and its expression increased in lung and heart and decreased in brain with increasing fetal/neonatal age. The developmental regulation of mouse CSF-1 expression appears to he important for mononuclear phagocyte development during this period. |
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Authors:
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P Roth; E R Stanley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 59 ISSN: 0741-5400 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-08-29 Completed Date: 1996-08-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 817-23 Citation Subset: IM |
Affiliation:
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Division of Neonatology, Department of Pediatrics, Albert Einstein College of Medicine, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Female Fetus / metabolism* Gene Expression Regulation, Developmental* Macrophage Colony-Stimulating Factor / analysis*, genetics Mice Mice, Inbred C57BL Pregnancy RNA, Messenger / analysis |
| Grant Support | |
ID/Acronym/Agency:
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CA 32551/CA/NCI NIH HHS; P30-CA13330/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 81627-83-0/Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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