Document Detail

Colony stimulating factor-1 expression is developmentally regulated in the mouse.
MedLine Citation:
PMID:  8691066     Owner:  NLM     Status:  MEDLINE    
Colony stimulating factor-1 (CSF-1) regulates the survival, proliferation, and differentiation of mononuclear phagocytes. To determine whether CSF-1 plays a role in the perinatal development of these cells, CSF-1 protein and mRNA expression in tissues and serum from fetal/neonatal mice and their mothers was analyzed. As fetal/neonatal age increased, CSF-1 concentrations rose in liver, kidney, and lung, declined in brain and serum, and did not change in intestine and heart. Concurrently, fetal/neonatal CSF-1 concentrations were higher in liver, kidney, and serum and lower in lung, brain, intestine, and heart than maternal tissue/serum concentrations, which showed no correlations with gestational or postpartum stage. CSF-1 mRNA was detected in all tissues examined and its expression increased in lung and heart and decreased in brain with increasing fetal/neonatal age. The developmental regulation of mouse CSF-1 expression appears to he important for mononuclear phagocyte development during this period.
P Roth; E R Stanley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of leukocyte biology     Volume:  59     ISSN:  0741-5400     ISO Abbreviation:  J. Leukoc. Biol.     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-29     Completed Date:  1996-08-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8405628     Medline TA:  J Leukoc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  817-23     Citation Subset:  IM    
Division of Neonatology, Department of Pediatrics, Albert Einstein College of Medicine, New York, USA.
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MeSH Terms
Animals, Newborn
Fetus / metabolism*
Gene Expression Regulation, Developmental*
Macrophage Colony-Stimulating Factor / analysis*,  genetics
Mice, Inbred C57BL
RNA, Messenger / analysis
Grant Support
Reg. No./Substance:
0/RNA, Messenger; 81627-83-0/Macrophage Colony-Stimulating Factor

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