| Colony-stimulating factor-1 exerts direct effects on the proliferation and invasiveness of endometrial epithelial cells. | |
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MedLine Citation:
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PMID: 21481374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although macrophage colony-stimulating factor (CSF-1) has been suggested to play a role in maintaining the chronic inflammatory response in endometriosis, our data suggest that CSF-1 may also play a role in early endometriosis lesion formation. We have shown that CSF-1, in an autocrine fashion, has a direct effect on endometrial epithelial cell proliferation and attachment to peritoneal mesothelial cells, early steps in endometriosis lesion formation on the peritoneum. |
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Authors:
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Sabitha Aligeti; Nameer B Kirma; Peter A Binkley; Robert S Schenken; Rajeshwar Rao Tekmal |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-04-09 |
Journal Detail:
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Title: Fertility and sterility Volume: 95 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-27 Completed Date: 2011-08-26 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2464-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Autocrine Communication Cell Adhesion Cell Line Cell Movement* Cell Proliferation* Coculture Techniques Endometriosis / metabolism*, pathology Endometrium / metabolism*, pathology Epithelial Cells / metabolism*, pathology Female Humans Macrophage Colony-Stimulating Factor / genetics, metabolism* Peritoneum / metabolism, pathology RNA Interference Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD049637/HD/NICHD NIH HHS; R01 HD049637-03/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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81627-83-0/Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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