Document Detail

Colonoscopy and SeHCAT for investigation of chronic diarrhea.
MedLine Citation:
PMID:  15205569     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Chronic diarrhea is a common problem. Colonoscopy is the investigation of choice for diagnosis. Even a macroscopically normal mucosa on endoscopy can have abnormalities such as microscopic colitis and bile acid malabsorption (BAM). The aim of this study was to establish the value of colonoscopy with biopsies in patients with chronic diarrhea and to evaluate the additive value of a SeHCAT test for diagnosing BAM in these patients. METHODS: All patients who underwent a colonoscopy between November 1999 and December 2000 were included. Patient files, colonoscopy and pathology reports and SeHCAT test results were reviewed. RESULTS: 205 patients were included. The most common diagnoses were diarrhea-predominant IBS (n = 76) and IBD (n = 38). 158 patients had non-bloody diarrhea, 113 (72%) of them had a macroscopically normal appearing mucosa. In 40 (35%) of these patients, a histological diagnosis could be made and microscopic colitis was the most common diagnosis (n = 27). SeHCAT test was performed in 36 patients and 15 (42%) of them had BAM. In the 47 patients with bloody diarrhea, IBD was the main diagnosis (n = 23). CONCLUSION: Colonoscopy with biopsies must be performed when investigating chronic diarrhea and BAM should be excluded.
Marcella Müller; Roger Willén; Per-Ove Stotzer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-06-16
Journal Detail:
Title:  Digestion     Volume:  69     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  2004  
Date Detail:
Created Date:  2004-08-06     Completed Date:  2004-11-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  211-8     Citation Subset:  IM    
Section of Gastroenterology and Hepatology, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg SE-413 45, Sweden.
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MeSH Terms
Bile Acids and Salts / pharmacokinetics*
Chronic Disease
Diarrhea / etiology*
Inflammatory Bowel Diseases / complications*,  diagnosis*
Intestinal Mucosa / pathology
Malabsorption Syndromes / diagnosis*
Retrospective Studies
Selenium Radioisotopes / diagnostic use*
Taurocholic Acid / diagnostic use*
Reg. No./Substance:
0/Bile Acids and Salts; 0/Selenium Radioisotopes; 81-24-3/Taurocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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