Document Detail


Colonization of second-trimester placenta parenchyma.
MedLine Citation:
PMID:  18313635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The overtly healthy, nonpregnant uterus harbors bacteria, Mycoplasma and Ureaplasma. The extent of colonization remains elusive, as are relationships between isolated microorganisms, preterm labor and fetal inflammation.
STUDY DESIGN: Biopsy specimens of chorion parenchyma from 1083 placentas delivered before the beginning of the 28th week of gestation were cultured, and the placentas were examined histologically. The frequencies of individual microorganisms and groups of microorganisms were evaluated in strata of processes leading to preterm delivery, routes of delivery, gestational age, and placenta morphology.
RESULTS: Placentas delivered by cesarean section with preeclampsia had the lowest bacterial recovery rate (25%). Preterm labor had the highest rates, which decreased with increasing gestational age from 79% at 23 weeks to 43% at 27 weeks. The presence of microorganisms in placenta parenchyma was associated with the presence of neutrophils in the fetal stem vessels of the chorion or in the vessels of the umbilical cord.
CONCLUSION: The high rate of colonization appears to coincide with phenomena associated with preterm delivery and gestational age. The presence of microorganisms within placenta parenchyma is biologically important.
Authors:
Andrew B Onderdonk; Jonathan L Hecht; Thomas F McElrath; Mary L Delaney; Elizabeth N Allred; Alan Leviton;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-03-07
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  199     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-07-22     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52.e1-52.e10     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cesarean Section
Female
Gestational Age
Humans
Obstetric Labor, Premature / microbiology*
Placenta / microbiology*,  pathology*
Pregnancy
Pregnancy Complications, Infectious*
Pregnancy Outcome
Pregnancy Trimester, Second
Grant Support
ID/Acronym/Agency:
5U01NS040069-05/NS/NINDS NIH HHS; U01 NS040069-05/NS/NINDS NIH HHS
Investigator
Investigator/Affiliation:
Bhavesh Shah / ; Solveg Pflueger / ; Glen Markenson / ; Camilia R Martin / ; Jonathon L Hecht / ; Bruce Cohen / ; Linda J Van Marter / ; Thomas McElrath / ; Alan Leviton / ; Robert Insoft / ; Drucilla Roberts / ; Laura Riley / ; Cynthia Cole / ; John Fiascone / ; Ina Bhan / ; Sabrina Craigo / ; Theresa Marino / ; Francis Bednarek / ; Gamze Ayata / ; Ellen Delpapa / ; Richard Ehrenkranz / ; Miguel Reyes-Múgica / ; Eduardo Zambrano / ; Keith P Williams / ; T Michael O'Shea / ; Dennis W Ross / ; Maggie Harper / ; Stephen Engelke / ; John Christie / ; Hamid Hadi / ; Carl Bose / ; Chad Livasy / ; Kim Boggess / ; Mariel Portenga / ; Barbara Doss / ; Curtis Cook / ; Padmani Karna / ; Gabriel Chamyan / ; Steve Roth / ; Michael D Schreiber / ; Aliya Husain / ; Mahmoud Ismail / ; Daniel Batton / ; Chung-ho Chang / ; Robert Lorenz / ; Harvey Kliman / ; Pat Senagore /
Comments/Corrections

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