| Colonization and epithelial adhesion in the pathogenesis of neonatal candidiasis. | |
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MedLine Citation:
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PMID: 14626499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Candida species are important nosocomial pathogens in the newborn population, particularly among the premature very-low-birth-weight infants in neonatal intensive care units. Candida colonization of the neonatal skin and gastrointestinal tract is an important first step in the pathogenesis of invasive disease. C albicans is the most commonly isolated species in colonized or infected infants. Over the past decade the incidence of both colonization and infection with other Candida species, particularly C parapsilosis, has risen dramatically. Colonization of the infant occurs early in life and is affected by a variety of common practices in neonatal intensive care. Microbial factors also augment colonization, including the ability of Candida to adhere to human epithelium. A better understanding of the complex interactions between host risk factors and virulence traits of colonizing yeast may allow the risk of systemic spread to be reduced in the population of premature infants. |
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Authors:
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Catherine M Bendel |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 27 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-11-19 Completed Date: 2004-03-04 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 357-64 Citation Subset: IM |
Affiliation:
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Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA. bende001@umn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Adhesion Candida / pathogenicity*, physiology Candidiasis / microbiology* Colony Count, Microbial Cross Infection / microbiology* Epithelium Fungemia / microbiology* Humans Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Intensive Care Units, Neonatal |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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